RPS6KB2 explained

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.^{[1] [2] [3]}

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Further reading

• Lee-Fruman KK . Characterization of S6K2, a novel kinase homologous to S6K1 . Oncogene . 18 . 36 . 5108–5114 . 1999 . 10490847 . 10.1038/sj.onc.1202894 . vanc. Kuo CJ . Lippincott J . 3 . Terada . Naohiro . Blenis . John . free .
• Koh H . Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt . Oncogene . 18 . 36 . 5115–5119 . 1999 . 10490848 . 10.1038/sj.onc.1202895 . vanc. Jee K . Lee B . 3 . Kim . Jeonghoon . Kim . Dohoon . Yun . Young-Ha . Kim . Jung Woo . Choi . Heung-Sik . Chung . Jongkyeong . free .
• Martin KA . Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway . J. Biol. Chem. . 276 . 11 . 7884–7891 . 2001 . 11108711 . 10.1074/jbc.M006969200 . vanc. Schalm SS . Richardson C . 3 . Romanelli . A . Keon . KL . Blenis . J . free.
• Martin KA . Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation . J. Biol. Chem. . 276 . 11 . 7892–7898 . 2001 . 11108720 . 10.1074/jbc.M009972200 . vanc. Schalm SS . Romanelli A . 3 . Keon . KL . Blenis . J . free .
• Minami T . Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha . Genes Cells . 6 . 11 . 1003–1015 . 2002 . 11733037 . 10.1046/j.1365-2443.2001.00479.x . vanc. Hara K . Oshiro N . 3 . Ueoku . Sachiko . Yoshino . Ken-Ichi . Tokunaga . Chiharu . Shirai . Yasuhito . Saito . Naoaki . Gout . Ivan . 24500851 . free .
• Pardo OE . Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells . Oncogene . 20 . 52 . 7658–7667 . 2002 . 11753643 . 10.1038/sj.onc.1204994 . vanc. Arcaro A . Salerno G . 3 . Tetley . Teresa D . Valovka . Taras . Gout . Ivan . Seckl . Michael J . free .
• Park IH, Bachmann R, Shirazi H, Chen J . Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin . J. Biol. Chem. . 277 . 35 . 31423–31429 . 2002 . 12087098 . 10.1074/jbc.M204080200 . free .
• Kanayasu-Toyoda T . Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells . Arch. Biochem. Biophys. . 405 . 1 . 21–31 . 2002 . 12176053 . 10.1016/S0003-9861(02)00330-2 . vanc. Yamaguchi T . Oshizawa T . 3 . Kogi . M . Uchida . E . Hayakawa . T .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Valovka T . Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization . Mol. Cell. Biol. . 23 . 3 . 852–863 . 2003 . 12529391 . 10.1128/MCB.23.3.852-863.2003 . 140705 . vanc. Verdier F . Cramer R . 3 . Zhyvoloup . A. . Fenton . T. . Rebholz . H. . Wang . M.-L. . Gzhegotsky . M. . Lutsyk . A. .
• Phin S, Kupferwasser D, Lam J, Lee-Fruman KK . Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1 . Biochem. J. . 373 . Pt 2 . 583–91 . 2003 . 12713446 . 10.1042/BJ20021794 . 1223513 .
• Kanayasu-Toyoda T . The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells . Biochem. Pharmacol. . 66 . 1 . 133–140 . 2003 . 12818373 . 10.1016/S0006-2952(03)00247-8 . vanc. Yamaguchi T . Oshizawa T . 3 . Uchida . E . Hayakawa . T .
• An WL . Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease . Am. J. Pathol. . 163 . 2 . 591–607 . 2003 . 12875979 . 10.1016/S0002-9440(10)63687-5. 1868198 . vanc. Cowburn RF . Li L . 3 . Braak . H . Alafuzoff . I . Iqbal . K . Iqbal . IG . Winblad . B . Pei . JJ .
• Shao J, Evers BM, Sheng H . Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells . Cancer Res. . 64 . 1 . 229–235 . 2004 . 14729629 . 10.1158/0008-5472.CAN-03-1859 . free .
• Lekmine F . Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein . Exp. Cell Res. . 295 . 1 . 173–182 . 2004 . 15051500 . 10.1016/j.yexcr.2003.12.021 . vanc. Sassano A . Uddin S . 3 . Smith . Jessica . Majchrzak . Beata . Brachmann . Saskia M . Hay . Nissim . Fish . Eleanor N . Platanias . Leonidas C .
• Raught B . Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases . EMBO J. . 23 . 8 . 1761–1769 . 2005 . 15071500 . 10.1038/sj.emboj.7600193 . 394247 . vanc. Peiretti F . Gingras AC . 3 . Livingstone . Mark . Shahbazian . David . Mayeur . Greg L . Polakiewicz . Roberto D . Sonenberg . Nahum . Hershey . John WB .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Saitoh M, ten Dijke P, Miyazono K, Ichijo H . Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases . Biochem Biophys Res Commun . 253 . 2 . 470–476 . Jan 1999 . 9878560 . 10.1006/bbrc.1998.9784 .
2. Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K . Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region . J Biol Chem . 273 . 46 . 30061–30064 . Dec 1998 . 9804755 . 10.1074/jbc.273.46.30061 . free .
3. Web site: Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2.