60S ribosomal protein L13a explained

60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative polyA signals have been observed. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in its second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

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• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Nicoloso M, Qu LH, Michot B, Bachellerie JP . Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs . J. Mol. Biol. . 260 . 2 . 178–195 . 1996 . 8764399 . 10.1006/jmbi.1996.0391 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Kenmochi N . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509 . vanc. Kawaguchi T . Rozen S . 3 . Davis . E . Goodman . N . Hudson . TJ . Tanaka . T . Page . DC. free .
• Higa S, Yoshihama M, Tanaka T, Kenmochi N . Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome . Gene . 240 . 2 . 371–377 . 2000 . 10580157 . 10.1016/S0378-1119(99)00429-1 . 25643638 .
• Andersen JS . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . vanc. Lyon CE . Fox AH . 3 . Leung . Anthony K.L. . Lam . Yun Wah . Steen . Hanno . Mann . Matthias . Lamond . Angus I. . 14132033 . free . 2002CBio...12....1A .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Odintsova TI . Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing . J. Protein Chem. . 22 . 3 . 249–258 . 2004 . 12962325 . 10.1023/A:1025068419698 . vanc. Müller EC . Ivanov AV . 3 . Egorov . Tsezi A. . Bienert . Ralf . Vladimirov . Serguei N. . Kostka . Susanne . Otto . Albrecht . Wittmann-Liebold . Brigitte . 10710245 .
• Mazumder B . Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control . Cell . 115 . 2 . 187–198 . 2003 . 14567916 . 10.1016/S0092-8674(03)00773-6 . vanc. Sampath P . Seshadri V . 3 . Maitra . Ratan K . Dicorleto . Paul E . Fox . Paul L . 14209529 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .

Notes and References

1. Web site: Entrez Gene: RPL13A ribosomal protein L13a.