RNF39 explained
RING finger protein 39 is a protein that in humans is encoded by the RNF39 gene.[1] [2]
This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Alternative splicing results in three transcript variants encoding different isoforms.[3]
Further reading
- Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
- Orimo A, Yamagishi T, Tominaga N, etal . Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC . Biochem. Biophys. Res. Commun. . 276 . 1 . 45–51 . 2000 . 11006080 . 10.1006/bbrc.2000.3380 .
- Hidaka M, Caruana G, Stanford WL, etal . Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells . Mech. Dev. . 90 . 1 . 3–15 . 2000 . 10585558 . 10.1016/S0925-4773(99)00234-8 . 673064 . free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
Notes and References
- Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J . Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes . Mamm Genome . 11 . 12 . 1127–31 . Dec 2000 . 11130983 . 10.1007/s003350010213 . 22881226 .
- Matsuo R, Asada A, Fujitani K, Inokuchi K . LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein . Biochem Biophys Res Commun . 289 . 2 . 479–84 . Nov 2001 . 11716498 . 10.1006/bbrc.2001.5975 .
- Web site: Entrez Gene: RNF39 ring finger protein 39.
