RNF125 explained

E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.^[1]

This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

Further reading

• Giannini AL, Gao Y, Bijlmakers MJ . T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. . Biochem. J. . 410 . 1 . 101–11 . 2008 . 17990982 . 10.1042/BJ20070995 . 2733222 .
• Shoji-Kawata S, Zhong Q, Kameoka M, etal . The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells. . Virology . 368 . 1 . 191–204 . 2007 . 17643463 . 10.1016/j.virol.2007.06.028 . free .
• Zhao H, Li CC, Pardo J, etal . A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. . J. Immunol. . 174 . 9 . 5288–97 . 2005 . 15843525 . 10.4049/jimmunol.174.9.5288. free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Chu P, Pardo J, Zhao H, etal . Systematic identification of regulatory proteins critical for T-cell activation. . J. Biol. . 2 . 3 . 21 . 2004 . 12974981 . 10.1186/1475-4924-2-21 . 333404 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Saurin AJ, Borden KL, Boddy MN, Freemont PS . Does this have a familiar RING? . Trends Biochem. Sci. . 21 . 6 . 208–14 . 1996 . 8744354 . 10.1016/s0968-0004(96)80017-x.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Web site: Entrez Gene: RNF125 ring finger protein 125.