RHOBTB1 explained

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.^{[1] [2]}

The protein encoded by this gene belongs to the Rho family, which is part of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, two tandem BTB (broad complex, tramtrack, and bric-à-brac) domains, and a conserved C-terminal region. This protein plays a role in small GTPase-mediated signal transduction and in the organization of the actin filament system. Alternative transcriptional splice variants of this gene have been characterized.^[3]

Further reading

• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 5 . 5 . 277–86 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . free . 10.1.1.529.4378 .
• Ramos S, Khademi F, Somesh BP, Rivero F . Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. . Gene . 298 . 2 . 147–57 . 2003 . 12426103 . 10.1016/S0378-1119(02)00980-0 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Aspenström P, Fransson A, Saras J . Rho GTPases have diverse effects on the organization of the actin filament system. . Biochem. J. . 377 . Pt 2 . 327–37 . 2004 . 14521508 . 10.1042/BJ20031041 . 1223866 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beder LB, Gunduz M, Ouchida M, etal . Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. . J. Cancer Res. Clin. Oncol. . 132 . 1 . 19–27 . 2006 . 16170569 . 10.1007/s00432-005-0033-0 . 35193238 .

Notes and References

1. Rivero F, Dislich H, Glockner G, Noegel AA . The Dictyostelium discoideum family of Rho-related proteins . Nucleic Acids Res . 29 . 5 . 1068–79 . Mar 2001 . 11222756 . 29714 . 10.1093/nar/29.5.1068 .
2. Web site: Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1.
3. Web site: Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1.