RGS5 explained

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.^{[1] [2]}

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.

Interactions

RGS5 has been shown to interact with GNAO1,^{[3] [4]} GNAI2^{[3] [4]} and GNAI3.^{[3] [4]}

Further reading

• Chen C, Zheng B, Han J, Lin SC . Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast . J. Biol. Chem. . 272 . 13 . 8679–85 . 1997 . 9079700 . 10.1074/jbc.272.13.8679 . free .
• Cismowski MJ, Takesono A, Ma C, etal . Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling . Nat. Biotechnol. . 17 . 9 . 878–83 . 1999 . 10471929 . 10.1038/12867 . 26981462 .
• Adams LD, Geary RL, McManus B, Schwartz SM . A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media . Circ. Res. . 87 . 7 . 623–31 . 2000 . 11009569 . 10.1161/01.res.87.7.623. 2390642 . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Zhou J, Moroi K, Nishiyama M, etal . Characterization of RGS5 in regulation of G protein-coupled receptor signaling . Life Sci. . 68 . 13 . 1457–69 . 2001 . 11253162 . 10.1016/S0024-3205(01)00939-0 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Morris DW, Rodgers A, McGhee KA, etal . Confirming RGS4 as a susceptibility gene for schizophrenia . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 125 . 1 . 50–3 . 2005 . 14755443 . 10.1002/ajmg.b.20109 . 45411595 .
• Berger M, Bergers G, Arnold B, etal . Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization . Blood . 105 . 3 . 1094–101 . 2005 . 15459006 . 10.1182/blood-2004-06-2315 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Liang Y, Li C, Guzman VM, etal . Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues . FEBS J. . 272 . 3 . 791–9 . 2005 . 15670159 . 10.1111/j.1742-4658.2004.04516.x . 13519368 .
• Adams LD, Geary RL, Li J, etal . Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap . Arterioscler. Thromb. Vasc. Biol. . 26 . 2 . 319–25 . 2006 . 16293795 . 10.1161/01.ATV.0000196647.45718.d6 . 14434603 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Rhee KH, Nam KH, Lee WH, etal . Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4- . Protein Pept. Lett. . 13 . 9 . 945–9 . 2007 . 17100651 . 10.2174/092986606778256225 .
• Bodenstein J, Sunahara RK, Neubig RR . N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells . Mol. Pharmacol. . 71 . 4 . 1040–50 . 2007 . 17220356 . 10.1124/mol.106.029397 . 11212754 .
• Yang Z, Gaudio S, Song W, etal . Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5) . Cell. Physiol. Biochem. . 20 . 5 . 303–10 . 2007 . 17762159 . 10.1159/000107516 . free .

Notes and References

1. Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T . Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene . J Hum Genet . 43 . 3 . 202–5 . October 1998 . 9747037 . 10.1007/s100380050071 . free .
2. Web site: Entrez Gene: RGS5 regulator of G-protein signalling 5.
3. Chen . C . Zheng B . Han J . Lin S C . March 1997 . Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast . J. Biol. Chem. . 272 . 13 . 8679–85 . UNITED STATES. 0021-9258. 9079700 . 10.1074/jbc.272.13.8679 . free .
4. Zhou . J . Moroi K . Nishiyama M . Usui H . Seki N . Ishida J . Fukamizu A . Kimura S . February 2001 . Characterization of RGS5 in regulation of G protein-coupled receptor signaling . Life Sci. . 68 . 13 . 1457–69 . England. 0024-3205. 11253162 . 10.1016/S0024-3205(01)00939-0 .