REG4 explained

Regenerating islet-derived protein 4 is a protein that in humans is encoded by the REG4 gene.^{[1] [2] [3]}

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kämäräinen M . RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa . Am. J. Pathol. . 163 . 1 . 11–20 . 2003 . 12819006 . 10.1016/S0002-9440(10)63625-5. 1868159 . vanc. Heiskala K . Knuutila S . 3 . Heiskala . M . Winqvist . O . Andersson . LC .
• Zhang Y . Overexpression of Reg IV in colorectal adenoma . Cancer Lett. . 200 . 1 . 69–76 . 2003 . 14550954 . 10.1016/S0304-3835(03)00460-9 . vanc. Lai M . Lv B . 3 . Gu . Xuemei . Wang . Huiping . Zhu . Yimin . Zhu . Yangli . Shao . Lina . Wang . Guofeng .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Gu Z . Reg IV: a promising marker of hormone refractory metastatic prostate cancer . Clin. Cancer Res. . 11 . 6 . 2237–43 . 2005 . 15788672 . 10.1158/1078-0432.CCR-04-0356 . vanc. Rubin MA . Yang Y . 3 . Deprimo . SE . Zhao . H . Horvath . S . Brooks . JD . Loda . M . Reiter . RE . free .
• Bishnupuri KS . Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas . Gastroenterology . 130 . 1 . 137–49 . 2006 . 16401477 . 10.1053/j.gastro.2005.10.001 . vanc. Luo Q . Murmu N . 3 . Houchen . C . Anant . S . Dieckgraefe . B .
• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . vanc. Barlow KF . McLay KE . 3 . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .
• Takehara A . Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4 . Cancer Sci. . 97 . 11 . 1191–7 . 2006 . 16918991 . 10.1111/j.1349-7006.2006.00297.x . vanc. Eguchi H . Ohigashi H . 3 . Ishikawa . Osamu . Kasugai . Tsutomu . Hosokawa . Masayo . Katagiri . Toyomasa . Nakamura . Yusuke . Nakagawa . Hidewaki . free . 11159249 .

Notes and References

1. Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK . Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV . Biochim Biophys Acta . 1518 . 3 . 287–93 . Apr 2001 . 11311942 . 10.1016/s0167-4781(00)00284-0.
2. Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T . Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas . Int J Cancer . 103 . 2 . 185–93 . Nov 2002 . 12455032 . 10.1002/ijc.10788 . free .
3. Web site: Entrez Gene: REG4 regenerating islet-derived family, member 4.