RASGRF2 explained

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.^[1]

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]^[2]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.^[3]

Further reading

• Fam NP, Zhang LJ, Rommens JM, etal . Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. . Genomics . 39 . 1 . 118–20 . 1997 . 9027497 . 10.1006/geno.1996.4484 .
• Fam NP, Fan WT, Wang Z, etal . Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. . Mol. Cell. Biol. . 17 . 3 . 1396–406 . 1997 . 9032266 . 10.1128/mcb.17.3.1396. 231864 .
• Fan WT, Koch CA, de Hoog CL, etal . The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. . Curr. Biol. . 8 . 16 . 935–8 . 1998 . 9707409 . 10.1016/S0960-9822(07)00376-4 . 8904502 . free . 1998CBio....8..935F .
• Anborgh PH, Qian X, Papageorge AG, etal . Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. . Mol. Cell. Biol. . 19 . 7 . 4611–22 . 1999 . 10373510 . 10.1128/mcb.19.7.4611. 84259 .
• Lutchman M, Kim AC, Cheng L, etal . Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. . Eur. J. Biochem. . 269 . 2 . 638–49 . 2002 . 11856323 . 10.1046/j.0014-2956.2001.02694.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Arozarena I, Matallanas D, Berciano MT, etal . Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. . Mol. Cell. Biol. . 24 . 4 . 1516–30 . 2004 . 14749369 . 10.1128/MCB.24.4.1516-1530.2004 . 344182 .
• Chen H, Suzuki M, Nakamura Y, etal . Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. . Oncol. Rep. . 15 . 5 . 1281–5 . 2006 . 16596198 . 10.3892/or.15.5.1281. free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Ruiz S, Santos E, Bustelo XR . RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. . Mol. Cell. Biol. . 27 . 23 . 8127–42 . 2007 . 17923690 . 10.1128/MCB.00912-07 . 2169177 .

Notes and References

1. Web site: Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2.
2. Web site: Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2.
3. News: Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say. Huffington Post. 3 December 2012.