RANBP9 explained

Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.^{[1] [2]}

Function

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.

Interactions

RANBP9 has been shown to interact with:

• Androgen receptor,^[3]
• C-Met,^[4]
• DISC1,^[5]
• DYRK1B,^[6]
• Glucocorticoid receptor,^[3]
• HIPK2^[7]
• MKLN1,^[8]
• S100A7,^[9] and
• USP11.^[10]

References

Further reading

• Nishimoto T . A new role of ran GTPase . Biochem. Biophys. Res. Commun. . 262 . 3 . 571–4 . 1999 . 10471364 . 10.1006/bbrc.1999.1252 .
• Kozak M . Emerging links between initiation of translation and human diseases . Mamm. Genome . 13 . 8 . 401–10 . 2003 . 12226704 . 10.1007/s00335-002-4002-5 . 25690586 .
• Nishitani H, Hirose E, Uchimura Y, Nakamura M, Umeda M, Nishii K, Mori N, Nishimoto T . Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex . Gene . 272 . 1–2 . 25–33 . 2001 . 11470507 . 10.1016/S0378-1119(01)00553-4 .
• Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J . Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) . Oncogene . 21 . 19 . 3003–10 . 2002 . 12082530 . 10.1038/sj.onc.1205390 . 20004395 .
• Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y . Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM . Biochem. J. . 367 . Pt 1 . 87–95 . 2003 . 12084015 . 1222860 . 10.1042/BJ20011851 .
• Wang D, Li Z, Messing EM, Wu G . Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM . J. Biol. Chem. . 277 . 39 . 36216–22 . 2002 . 12147692 . 10.1074/jbc.M205111200 . free .
• Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H . HIPK2 associates with RanBPM . Biochem. Biophys. Res. Commun. . 297 . 1 . 148–53 . 2002 . 12220523 . 10.1016/S0006-291X(02)02020-X .
• Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS . RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor . J. Biol. Chem. . 277 . 50 . 48020–7 . 2003 . 12361945 . 10.1074/jbc.M209741200 . free .
• Emberley ED, Gietz RD, Campbell JD, HayGlass KT, Murphy LC, Watson PH . RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer . BMC Cancer . 2 . 28 . 2003 . 12421467 . 137593 . 10.1186/1471-2407-2-28 . free .
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B . Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin . Biochem. Biophys. Res. Commun. . 299 . 5 . 793–800 . 2003 . 12470648 . 10.1016/S0006-291X(02)02718-3 .
• Umeda M, Nishitani H, Nishimoto T . A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM . Gene . 303 . 47–54 . 2003 . 12559565 . 10.1016/S0378-1119(02)01153-8 .
• Lutz W, Frank EM, Craig TA, Thompson R, Venters RA, Kojetin D, Cavanagh J, Kumar R . Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy . Biochem. Biophys. Res. Commun. . 303 . 4 . 1186–92 . 2003 . 12684061 . 10.1016/S0006-291X(03)00499-6 .
• Yao X, Wang HL, Shi ZX, Yan XY, Feng EL, Yang BL, Huang LY . Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast . World J. Gastroenterol. . 9 . 6 . 1347–51 . 2003 . 12800254 . 4611814 . 10.3748/wjg.v9.i6.1347 . free .
• Morris JA, Kandpal G, Ma L, Austin CP . DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation . Hum. Mol. Genet. . 12 . 13 . 1591–608 . 2004 . 12812986 . 10.1093/hmg/ddg162 .
• Zou Y, Lim S, Lee K, Deng X, Friedman E . Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M . J. Biol. Chem. . 278 . 49 . 49573–81 . 2004 . 14500717 . 10.1074/jbc.M307556200 . free .
• Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M . The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM . Biochem. Biophys. Res. Commun. . 310 . 1 . 14–8 . 2003 . 14511641 . 10.1016/j.bbrc.2003.08.116 .

Notes and References

1. Nakamura M, Masuda H, Horii J, ((Kuma Ki)), Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T . When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin . J Cell Biol . 143 . 4 . 1041–52 . Dec 1998 . 9817760 . 2132962 . 10.1083/jcb.143.4.1041 .
2. Web site: Entrez Gene: RANBP9 RAN binding protein 9.
3. Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS . RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor . J. Biol. Chem. . 277 . 50 . 48020–7 . Dec 2002 . 12361945 . 10.1074/jbc.M209741200 . free .
4. Wang D, Li Z, Messing EM, Wu G . Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM . J. Biol. Chem. . 277 . 39 . 36216–22 . Sep 2002 . 12147692 . 10.1074/jbc.M205111200 . free .
5. Morris JA, Kandpal G, Ma L, Austin CP . DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation . Hum. Mol. Genet. . 12 . 13 . 1591–608 . Jul 2003 . 12812986 . 10.1093/hmg/ddg162.
6. Zou Y, Lim S, Lee K, Deng X, Friedman E . Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M . J. Biol. Chem. . 278 . 49 . 49573–81 . Dec 2003 . 14500717 . 10.1074/jbc.M307556200 . free .
7. Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H . HIPK2 associates with RanBPM . Biochem. Biophys. Res. Commun. . 297 . 1 . 148–53 . Sep 2002 . 12220523 . 10.1016/S0006-291X(02)02020-X.
8. Umeda M, Nishitani H, Nishimoto T . A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM . Gene . 303 . 47–54 . Jan 2003 . 12559565 . 10.1016/s0378-1119(02)01153-8.
9. Emberley ED, Gietz RD, Campbell JD, HayGlass KT, Murphy LC, Watson PH . RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer . BMC Cancer . 2 . 28 . Nov 2002 . 12421467 . 137593 . 10.1186/1471-2407-2-28 . free .
10. Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y . Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM . Biochem. J. . 367 . Pt 1 . 87–95 . Oct 2002 . 12084015 . 1222860 . 10.1042/BJ20011851 .