RAGE (gene) explained

MAPK/MAK/MRK overlapping kinase is an enzyme that in humans is encoded by the RAGE gene.^{[1] [2] [3]}

Further reading

• Eichmüller S, Usener D, Jochim A, Schadendorf D . mRNA expression of tumor-associated antigens in melanoma tissues and cell lines . Experimental Dermatology . 11 . 4 . 292–301 . August 2002 . 12190937 . 10.1034/j.1600-0625.2002.110402.x . 22559064 .
• Götte K, Usener D, Riedel F, Hörmann K, Schadendorf D, Eichmüller S . Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes . Acta Oto-Laryngologica . 122 . 5 . 546–52 . July 2002 . 12206267 . 10.1080/00016480260092381 . 7087339 .
• Yan M, Ghorab Z, Nadji M . Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas . Applied Immunohistochemistry & Molecular Morphology . 11 . 2 . 113–5 . June 2003 . 12777992 . 10.1097/00129039-200306000-00003 . 29045611 .
• Miura J, Uchigata Y, Yamamoto Y, Takeuchi M, Sakurai S, Watanabe T, Yonekura H, Yamagishi S, Makita Z, Sato A, Omori Y, Yamamoto H, Iwamoto Y . AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes . Journal of Diabetes and Its Complications . 18 . 1 . 53–9 . 2004 . 15019601 . 10.1016/S1056-8727(02)00281-7 .
• Rudofsky G, Isermann B, Schilling T, Schiekofer S, Andrassy M, Schneider JG, Morcos M, Humpert PM, Sayed AA, Witte S, Renn W, Pfohl M, Hamann A, Nosikov V, Schleicher E, Häring HU, Rudofsky G, Ritz E, Nawroth PP, Bierhaus A . A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes . Experimental and Clinical Endocrinology & Diabetes . 112 . 3 . 135–41 . March 2004 . 15052533 . 10.1055/s-2004-817822 . 260134909 .
• Uesaka T, Kageyama N . Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells . FEBS Letters . 573 . 1–3 . 147–54 . August 2004 . 15327990 . 10.1016/j.febslet.2004.07.070 . 42372904 .
• Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundörfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Stern DM, Arnold B, Nawroth PP . Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily . The Journal of Clinical Investigation . 114 . 12 . 1741–51 . December 2004 . 15599399 . 535062 . 10.1172/JCI18058 .
• Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A . Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer . Genes, Chromosomes & Cancer . 43 . 1 . 11–24 . May 2005 . 15704127 . 10.1002/gcc.20155 . 38956616 .
• dos Santos KG, Canani LH, Gross JL, Tschiedel B, Pires Souto KE, Roisenberg I . The -374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes . Molecular Genetics and Metabolism . 85 . 2 . 149–56 . June 2005 . 15896660 . 10.1016/j.ymgme.2005.02.010 .
• Oehlrich N, Devitt G, Linnebacher M, Schwitalle Y, Grosskinski S, Stevanovic S, Zöller M . Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma . International Journal of Cancer . 117 . 2 . 256–64 . November 2005 . 15900605 . 10.1002/ijc.21200 . free .
• Dumitriu IE, Baruah P, Bianchi ME, Manfredi AA, Rovere-Querini P . Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells . European Journal of Immunology . 35 . 7 . 2184–90 . July 2005 . 15915542 . 10.1002/eji.200526066 . free .
• Haslbeck KM, Friess U, Schleicher ED, Bierhaus A, Nawroth PP, Kirchner A, Pauli E, Neundörfer B, Heuss D . The RAGE pathway in inflammatory myopathies and limb girdle muscular dystrophy . Acta Neuropathologica . 110 . 3 . 247–54 . September 2005 . 15986224 . 10.1007/s00401-005-1043-3 . 19040474 .
• Ramprasad S, Radha V, Mathias RA, Majumder PP, Rao MR, Rema M . Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India . Eye . 21 . 3 . 395–401 . March 2007 . 16440015 . 10.1038/sj.eye.6702239 . free .
• Lindholm E, Bakhtadze E, Sjögren M, Cilio CM, Agardh E, Groop L, Agardh CD . The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients . Diabetologia . 49 . 11 . 2745–55 . November 2006 . 16969646 . 10.1007/s00125-006-0412-3 . free .
• Dumitriu IE, Bianchi ME, Bacci M, Manfredi AA, Rovere-Querini P . The secretion of HMGB1 is required for the migration of maturing dendritic cells . Journal of Leukocyte Biology . 81 . 1 . 84–91 . January 2007 . 17035340 . 10.1189/jlb.0306171 . 43269992 .

Notes and References

1. Gaugler B, Brouwenstijn N, Vantomme V, Szikora JP, Van der Spek CW, Patard JJ, Boon T, Schrier P, Van den Eynde BJ . A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma . Immunogenetics . 44 . 5 . 323–30 . Oct 1996 . 8781117 . 10.1007/BF02602776 . 20056364 .
2. Miyata Y, Akashi M, Nishida E . Molecular cloning and characterization of a novel member of the MAP kinase superfamily . Genes to Cells . 4 . 5 . 299–309 . May 1999 . 10421840 . 10.1046/j.1365-2443.1999.00261.x . free .
3. Web site: Entrez Gene: RAGE renal tumor antigen.