| Country: | ZAF |
| Type: | R |
| Route: | 22 |
| Maint: | SANRAL |
| Map: | Map of the R22 (South Africa).svg |
| Length Km: | 170 |
| Direction A: | South |
| Terminus A: | near Hluhluwe |
| Direction B: | North |
| Terminus B: | Mozambique border at Kosi Bay |
| Previous Type: | R |
| Previous Route: | 21 |
| Next Type: | R |
| Next Route: | 23 |
The R22 is a provincial route in the KwaZulu-Natal province of South Africa, connecting the N2 at Hluhluwe with the Mozambique border at Kosi Bay, via Mbazwana and Kwangwanase. It was opened on 25 October 2008.[1] [2]