| Province: | QC |
| Type: | QC |
| Route: | 301 |
| Maint: | Transports Québec |
| Map: | Route 301-QC.png |
| Length Km: | 81.1 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction B: | North |
| Direction A: | South |
| Terminus B: | in Kazabazua |
| Terminus A: | at the Ontario border (formerly) |
| Previous Type: | QC |
| Previous Route: | 299 |
| Next Type: | QC |
| Next Route: | 303 |
| Counties: | Pontiac / La Vallée-de-la-Gatineau |
| Junction: | in Portage-du-Fort in Campbell's Bay in Thorne in Otter Lake |
Route 301 is an 81.1adj=midNaNadj=mid provincial highway located in the Outaouais region in western Quebec. The route serves as a direct connection between the Pontiac region and the Upper Gatineau region. The 82-kilometer route runs from the end of Ontario Highway 653 near Portage-du-Fort and joins Route 148 for a 9km (06miles) stretch up to Campbell's Bay where it continues eastward and ends in Kazabazua at the junction of Route 105.