| Official Name: | Puerto Santa Cruz |
| Other Name: | Puerto Santa Cruz |
| Settlement Type: | Municipality and town |
| Pushpin Map: | Argentina Santa Cruz#Argentina |
| Pushpin Map Caption: | Location of Puerto Santa Cruz in Argentina |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type2: | Department |
| Subdivision Name2: | Corpen Aike Department |
| Established Date: | 12 December 1878 |
| Unit Pref: | Imperial |
| Population As Of: | 2010 |
| Population Total: | 4431 |
| Utc Offset: | -03:00 |
| Coordinates: | -50.0167°N -68.5167°W |
| Postal Code Type: | Postal codes in Argentina |
| Postal Code: | 9300 |
| Area Code: | 02962 |
| Blank Name Sec1: | Climate |
| Blank Info Sec1: | BSk |
Puerto Santa Cruz is a town and municipality in Santa Cruz Province in southern Argentina.[1] It lies near the Atlantic coast on the northern bank of the estuary of Santa Cruz River. It is the second oldest city in the province, being founded in 1878. It was the capital of the Santa Cruz National Territory until Río Gallegos took over the position in 1888. The town is a local centre for sheep and cattle farming. The presence of fresh water in an otherwise semi-arid environment allows for orchards and a local horticulture.
It is located at latitude 50°S and is an antipode of Prague (located at latitude 50°N).