| Competition: | Primera División de México |
| Season: | 2000−01 |
| Winners: | Morelia (1st title) |
| Continentalcup1: | Champions' Cup |
| Continentalcup1 Qualifiers: | Morelia |
| Continentalcup2: | Copa Libertadores |
| Continentalcup2 Qualifiers: | Cruz Azul |
| Continentalcup3: | CONCACAF Giants Cup |
| Continentalcup3 Qualifiers: | América Guadalajara |
| League Topscorer: | Jared Borgetti (18 goals) |
| Prevseason: | Verano 2000 |
| Nextseason: | Verano 2001 |
Primera División de México (Mexican First Division) Invierno 2000 is a Mexican football tournament - one of two short tournaments that take up the entire year to determine the champion(s) of Mexican football. It began on Saturday, July 29, 2000, and ran until November 18, when the regular season ended. Irapuato was promoted to the Primera División de México thus, Toros Neza was relegated to the Primera División A. Morelia defeated Toluca in the final and were crowned Champions for the first, and to date, the only time.
Players sorted first by goals scored, then by last name. Only regular season goals listed.
| Rank | Player | Club | Goals | ||
|---|---|---|---|---|---|
| align=center rowspan=1 | 1 |  Jared Borgetti | Santos Laguna | align=center rowspan=1 | 18 |
| align=center rowspan=1 | 2 |  Ángel Morales | Cruz Azul | align=center rowspan=1 | 12 |
| align=center rowspan=2 | 3 | Antonio de Nigris | Monterrey | align=center rowspan=2 | 11 |
| Daniel Osorno | Atlas | ||||
| align=center rowspan=2 | 5 | Carlos Pavón | Morelia | align=center rowspan=2 | 10 |
| Martín Rodríguez | Irapuato | ||||
| align=center rowspan=2 | 7 | Armando González | Celaya | align=center rowspan=2 | 9 |
| Julio César Yegros | UNAM | ||||
| align=center rowspan=6 | 9 |  Adelino Batista | León | align=center rowspan=6 | 8 |
| Alejandro Glaría | Puebla | ||||
| Carlos María Morales | Toluca | ||||
| Cristián Morales | Irapuato | ||||
| Francisco Palencia | Cruz Azul | ||||
| Jafet Soto | UAG |
Source: MedioTiempo
Morelia won 7–3 on aggregate.
4–4 on aggregate. Toluca advanced for being the higher seeded team.----
Atlas won 2–1 on aggregate.----
Morelia won 2–1 on aggregate.----
Santos Laguna won 4–3 on aggregate.
Toluca won 6–4 on aggregate.----
Morelia won 3–2 on aggregate.
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3–3 on aggregate. Morelia won 5–4 on penalty kicks.
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