Povorcitinib Explained
| Legal Status: | Investigational |
| Cas Number: | 1637677-22-5 |
| Pubchem: | 86280672 |
| Iuphar Ligand: | 11881 |
| Drugbank: | DB18855 |
| Chemspiderid: | 115010428 |
| Unii: | N0JWC7RO00 |
| Kegg: | D12575 |
| Chembl: | 5095079 |
| Synonyms: | INCB-054707 |
| Iupac Name: | 4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide |
| C: | 23 |
| H: | 22 |
| F: | 5 |
| N: | 7 |
| O: | 1 |
| Smiles: | CC1=C(C(=NN1)C)C2=CN(N=C2)C3(CN(C3)C4=C(C=C(C(=C4)F)C(=O)N[C@@H](C)C(F)(F)F)F)CC#N |
| Stdinchi: | 1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/m0/s1 |
| Stdinchikey: | MSGYSFWCPOBHEV-AWEZNQCLSA-N |
Povorcitinib is an investigational new drug that is being evaluated for the treatment of the skin conditions hidradenitis suppurativa[1] [2] and chronic prurigo.[3] [4] It is a JAK1 inhibitor.[5]
Notes and References
- Alavi A, Hamzavi I, Brown K, Santos LL, Zhu Z, Liu H, Howell MD, Kirby JS. Janus kinase 1 inhibitor INCB054707 for patients with moderate-to-severe hidradenitis suppurativa: results from two phase II studies. Br J Dermatol. 2022 May;186(5):803-813.
- Kirby JS, Okun MM, Alavi A, Bechara FG, Zouboulis CC, Brown K, Santos LL, Wang A, Bibeau KB, Kimball AB, Porter ML. Efficacy and safety of the oral Janus kinase 1 inhibitor povorcitinib (INCB054707) in patients with hidradenitis suppurativa in a phase 2, randomized, double-blind, dose-ranging, placebo-controlled study. J Am Acad Dermatol. 2024 Mar;90(3):521-529.
- Web site: Povorcitinib - Incyte Corporation . AdisInsight . Springer Nature Switzerland AG .
- Thünemann J, Müller S, Steinbrink K, Ständer S, Zeidler C . Chronic Prurigo . Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG . 22 . 6 . 813–823 . June 2024 . 38722190 . 10.1111/ddg.15317 . free .
- Liao V, Cornman HL, Ma E, Kwatra SG . Prurigo nodularis: new insights into pathogenesis and novel therapeutics . The British Journal of Dermatology . 190 . 6 . 798–810 . May 2024 . 38345154 . 10.1093/bjd/ljae052 . 11099982 . February 12, 2025 .
