| Official Name: | Piopolis, Illinois |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Illinois#USA |
| Pushpin Label: | Piopolis |
| Pushpin Label Position: | top |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Illinois |
| Subdivision Type2: | County |
| Subdivision Name2: | Hamilton |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 410 |
| Coordinates: | 38.1836°N -88.5614°W |
| Area Code: | 618 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 415732 |
Piopolis is an unincorporated community in Hamilton County, Illinois, United States. Piopolis is located in Crouch Township, 2.5miles south of Belle Prairie City.
Piopolis was settled in 1841 by Roman Catholic immigrants from Baden, Germany. It was known as Auxier Prairie, Dutch Settlement, Mount St. John, St. Francis Xavier, and Belle Prairie before being named Piopolis in 1877 after Pope Pius IX. Piopolis once had a post office, which opened in 1848, and a public school which operated from the 1880s to the 1920s. The community's economy has historically been based on farming.[1]