| Official Name: | Pilsupiai |
| Settlement Type: | Village |
| Pushpin Map: | Kėdainiai District Municipality#Lithuania |
| Pushpin Map Caption: | Location in Lithuania |
| Subdivision Name: |  Lithuania |
| Subdivision Type1: | County |
| Subdivision Name1: | Kaunas County |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Kėdainiai district municipality |
| Subdivision Type3: | Eldership |
| Subdivision Name3: | Krakės Eldership |
| Population As Of: | 2011 |
| Population Total: | 54 |
| Timezone: | EET |
| Utc Offset: | +2 |
| Timezone Dst: | EEST |
| Utc Offset Dst: | +3 |
| Coordinates: | 55.3139°N 23.6831°W |
Pilsupiai (formerly ru|Пилсупе, pl|Piłsupie) is a village in Kėdainiai district municipality, in Kaunas County, in central Lithuania. According to the 2011 census, the village had a population of 54 people. It is located from Krakės, along the Krakės-Josvainiai road, on the right bank of the Šušvė river (the Angiriai Reservoir), by its tributary Paupelys (or Pilsupys) mouth.
There is the Pilsupiai hillfort (Bakanas hill) on the confluence of the rivers. Nearby, a nature monument the Piluspiai outcrop is located on the shore of the Angiriai Reservoir. away from Pilsupiai, at the former Skinderiškis estate place the Skinderiškis Dendrological Park is located.
Pilsupiai village is known since 1596. The first primary school was established here at the end of the 19th century.