Pierson Creek is a stream in Woodbury County and Cherokee County, in the US state of Iowa. It is a tributary of the Little Sioux River.
The headwaters are at 42.6611°N -95.7753°W and the confluence with the Little Sioux are at 42.4828°N -95.7928°W.
The name of the stream was named after Andrew Pierson, a pioneer settler.[1]