Philip Seeman Explained
Philip Seeman, (8 February 1934 – 9 January 2021) was a Canadian schizophrenia researcher and neuropharmacologist, known for his research on dopamine receptors.[1]
Career
Born in Winnipeg, Manitoba, Seeman was raised in Montreal. He received a Bachelor of Science degree, honours physics & physiology (1955), a Master of Science degree, physiology of transport & secretion (1956), and a Doctor of Medicine (1960) from McGill University. In 1966, he received a Ph.D. in life sciences from Rockefeller University under the supervision of George Emil Palade.[2]
In 1967, Seeman became an assistant professor in the Department of Pharmacology at the University of Toronto. In 1970, he was appointed a professor.
In 1974, having spent years in search of the binding site of antipsychotic medication, he discovered the dopamine D2 receptor, the basis for the dopamine hypothesis of schizophrenia.[3] [4] His discoveries also helped advance research on other diseases involving dopamine, such as Parkinson's disease and Huntington's disease.[2]
In 2001, he was made an Officer of the Order of Canada "for his research on dopamine receptors and their involvement in diseases such as schizophrenia, Parkinson's and Huntington's".
In 1985, he was made a Fellow of the Royal Society of Canada.[5]
He was married to Dr. Mary V. Seeman.[6]
References
- Madras . B.K. . 2013 . History of the discovery of the antipsychotic dopamine D2 receptor: A basis for the dopamine hypothesis of schizophrenia . Journal of the History of the Neurosciences: Basic and Clinical Perspectives . 22 . 1. 62–78 . 10.1080/0964704x.2012.678199. 23323533 . 12002684 .
- Seeman . P. . 2011 . All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2High receptors . CNS Neuroscience & Therapeutics . 17 . 2. 118–132 . 10.1111/j.1755-5949.2010.00162.x. 20560996 . 6493870 .
- P. Seeman (2010). "Dopamine D2 Receptors as Treatment Targets in Schizophrenia. Clinical Schizophrenia & Related Psychoses April: 56-73.
- P. Seeman (2007), Scholarpedia, 2(10): 3634 doi.4249/scholarpedia.3634
- Seeman . P. . 2006 . Targeting the dopamine D2 receptor in schizophrenia . Expert Opinion on Therapeutic Targets . 10 . 4. 515–531 . 10.1517/14728222.10.4.515. 16848689 . 30902536 .
- Seeman . P. . Weinshenker . D. . Quirion . R. . Srivastava . L. . Bhardwaj . S.K. . Grandy . D.K. . Premont . R. . Sotnikova . T. . Boksa . P. . El-Ghundi . M. . O'Dowd . B.F. . George . S.R. . Perreault . M.L. . Mannisto . P.T. . Robinson . S. . Palmiter . R.D. . Tallerico . T. . 2005 . Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis . Proceedings of the National Academy of Sciences USA . 102 . 9. 3513–3518 . 10.1073/pnas.0409766102 . 15716360 . 548961 . 2005PNAS..102.3513S. free .
- Seeman . P. . Chau-Wong . M. . Tedesco . J. . Wong . K. . 1975 . Brain receptors for antipsychotic drugs and dopamine: Direct binding assays . Proceedings of the National Academy of Sciences, USA . 72 . 11. 4376–4380 . 10.1073/pnas.72.11.4376 . 1060115 . 388724. 1975PNAS...72.4376S . free .
External links
Notes and References
- Web site: Philip SEEMAN . The Globe and Mail . 19 January 2021.
- Web site: Peters . Diane . Researcher Philip Seeman shed new light on biology of schizophrenia . The Globe and Mail . 15 August 2024 . 27 January 2021.
- P. Seeman, M. Chau-Wong, J. Tedesco & K. Wong. Brain receptors for antipsychotic drugs and dopamine: direct binding assays. Proceedings of the National Academy of Sciences of the United States of America. 72. 11. 4376–4370. November 1975. 1060115. 388724. 10.1073/pnas.72.11.4376. 1975PNAS...72.4376S. free.
- People. CMAJ. 1994. 151. 8. 1186–1187. 1337253.
- Web site: Science & Medicine - Science & Medicine . www.sciandmed.com . dead . https://web.archive.org/web/20110716014909/http://www.sciandmed.com/sm/journalviewer.aspx?issue=1066&article=787&action=1 . 2011-07-16.
- News: Most Wikipedia profiles are about men – these women in Australia are hoping to change that . 27 July 2019 . SBS News . en.
