Peter Openshaw (immunologist) explained
Peter Openshaw |
Birth Date: | 11 November 1954 |
Birth Place: | Glastonbury, Somerset, England |
Fields: | Immunology |
Workplaces: | Imperial College London |
Alma Mater: | Guy's Hospital |
Thesis Title: | Benefit and harm from immunity to respiratory syncytial virus |
Thesis Url: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238236 |
Thesis Year: | 1988 |
Peter John Morland Openshaw, (born 11 November 1954) is a British clinician and scientist specialising in lung immunology, particularly defence against viral infections. He trained in lung diseases and undertook a PhD in immunology before establishing a laboratory at St Mary's Hospital Medical School (later part of Imperial College London). He created the academic department of Respiratory Medicine and the Centre for Respiratory Infection at Imperial College and was elected President of the British Society for Immunology in 2014.
Early life
Openshaw was born in 1954 in Glastonbury, Somerset. He attended Millfield Junior School, then the Quaker boarding schools Sidcot School and Bootham School, followed by Guy's Hospital Medical School (University of London). He earned an intercalated BSc in Physiology (Hons., 1976), qualified in medicine (MB BS, 1979), and worked at the Royal Brompton Hospital and as medical registrar at Royal Postgraduate Medical School (Hammersmith Hospital).
Career
- Immunological workOriginally trained in lung mechanics, his PhD at the National Institute for Medical Research at Mill Hill, London was in T cell immunology.[1] He has worked on protective and harmful immunological reactions to viruses, inflammatory lung disease and vaccine development since 1985, writing over 300 scientific articles (h-index= 101).[2] He was President of the British Society for Immunology between 2013 and 2018, the first clinician to hold the role. Openshaw was a member of the Academy of Medical Sciences and British Society for Immunology expert taskforce on COVID-19.[3]
- Respiratory virus researchHe was awarded the Chanock prize (2012, Santa Fe USA) in recognition of his lifetime achievement in work on respiratory syncytial virus (RSV) research. He has been involved in influenza policy since 2002 as a member of UK advisory boards and was Vice President of European Scientific Working Group on Influenza (ESWI) from 2009-2014. In 2009 he set up the MOSAIC consortium, a collaboration of 45 co-investigators studying the host response to influenza in patients admitted to 11 hospitals in London and Liverpool (Wellcome Trust/MRC support) and directs studies of viral challenge of human volunteers.
He was Theme Lead for the Respiratory Theme and later the Infection Theme of the NIHR Imperial Biomedical Research Centre. Currently he works as Head of the Respiratory Infections Section at the National Heart and Lung Institute, a department of Imperial College London.
- Academic leadershipOpenshaw established the academic department of Respiratory Medicine on the St Mary’s Campus of Imperial College and created the Centre for Respiratory Infection (Wellcome Trust funded). He has sat on numerous governmental, grant awarding and international committees.
He was elected an Imperial College Consul for the Faculty of Medicine in 2016, becoming Senior Consul in 2019[4] and then Proconsul.[5] He co-chaired Imperial's Working Together Task Group in 2021.[6]
- AdvisoryOpenshaw is a member of the New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) in the UK.[7]
Honours
Openshaw is a Fellow of the Royal College of Physicians (1994), a Fellow of the Academy of Medical Sciences (1999) and a Fellow of the Society of Biology (2014).[8] He was selected as Senior Investigator by National Institute for Health Research (NIHR) in 2013 and 2020.[9] [10]
Openshaw was appointed Commander of the Order of the British Empire (CBE) in the 2022 New Year Honours for services to medicine and immunology.
Selected publications
- Hansel . TT . Johnston . SL . Openshaw . PJ . 2013 . Microbes and mucosal immune responses in asthma . 10.1016/S0140-6736(12)62202-8 . 23428115 . Lancet . 381 . 9869 . 861–873 . 24596808 .
- Chiu . C . Openshaw . PJ . 2015 . Antiviral B cell and T cell immunity in the lungs . Nature Immunology . 16 . 1 . 18–26 . 10.1038/ni.3056 . 25521681 . 7097128.
- Habibi . Maximillian S. . Thwaites . Ryan S. . Openshaw . Peter . Jozwik . Agnieszka . Paras . Allan . Kirsebom . Freja . Varese . Augusto . Owen . Amber . Cuthbertson . Leah . James . Phillip . Tunstall . Tanushree . Nickle . David . Hansel . Trevor T. . Moffatt . Miriam F. . Johansson . Cecilia . 3 . 2020-10-09 . Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection . Science . en . 370 . 6513 . 10.1126/science.aba9301 . 0036-8075 . 7613218 . 33033192.
- Thwaites . Ryan S . Sanchez Sevilla Uruchurtu . Ashley . Openshaw . Peter . Liew . Felicity . Russell . Clark D . Moore . Shona C . Fairfield . Cameron . Carter . Edwin . Abrams . Simon . Short . Charlotte-Eve . Thaventhiran . Thilipan . Bergstrom . Emma . Gardener . Zoe . Ascough . Stephanie . Chiu . Christopher . 3 . 2021-03-04 . Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 . Science Immunology . en . 6 . 57 . 10.1126/sciimmunol.abg9873 . 33692097 . 8128298 . 2470-9468.
- Openshaw . Peter J. M. . 2022-01-07 . Using correlates to accelerate vaccinology . Science . en . 375 . 6576 . 22–23 . 10.1126/science.abn0007 . 34990231 . 2022Sci...375...22O . 0036-8075.
- Pairo-Castineira . Erola . Rawlik . Konrad . Openshaw . Peter . Qi . Ting . Wu . Yang . Nassiri . Isar . McConkey . Glenn A. . Zechner . Marie . Klaric . Lucija . Griffiths . Fiona . Oosthuyzen . Wilna . Kousathanas . Athanasios . Richmond . Anne . Millar . Jonathan . Russell . Clark D. . 3 . 2023-05-25 . GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 . Nature . en . 617 . 7962 . 764–768 . 10.1038/s41586-023-06034-3 . 0028-0836 . 10208981 . 37198478.
- Thwaites . Ryan S. . Uruchurtu . Ashley S. S. . Openshaw . Peter . Cole . Megan E. . Singh . Nehmat . Poshai . Nelisa . Jackson . David . Hoschler . Katja . Baker . Tina . Scott . Ian C. . Ros . Xavier Romero . Cohen . Emma Suzanne . Zambon . Maria . Pollock . Katrina M. . Hansel . Trevor T. . 3 . 2023-12-05 . Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine . Nature Communications . en . 14 . 1 . 8053 . 10.1038/s41467-023-43842-7 . 2041-1723 . 10697962 . 38052824. 2023NatCo..14.8053T .
- Sidhu . Jasmin K . Siggins . Matthew K . Openshaw . Peter J M . Russell . Clark D . Uruchurtu . Ashley S S . Davis . Christopher . Turtle . Lance . Moore . Shona C . Hardwick . Hayley E . Oosthuyzen . Wilna . Thomson . Emma C . Semple . Malcolm G . Baillie . J Kenneth . Thwaites . Ryan S . 3 . 2023-12-22 . Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 . The Journal of Infectious Diseases . en . 10.1093/infdis/jiad590 . 38134401 . 0022-1899. 20.500.11820/bed8141e-e4f2-482e-beae-1d084fe9ae37 . free .
- Wagstaffe . Helen R. . Thwaites . Ryan S. . Openshaw . Peter . Sidhu . Jasmin K. . McKendry . Richard . Ascough . Stephanie . Papargyris . Loukas . Collins . Ashley M. . Xu . Jiayun . Lemm . Nana-Marie . Siggins . Matthew K. . Chain . Benny M. . Killingley . Ben . Kalinova . Mariya . Mann . Alex . 3 . 2024-09-02 . Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults . Science Immunology . en . 9 . 92 . eadj9285 . 10.1126/sciimmunol.adj9285 . 38335268 . 2470-9468.
Notes and References
- Web site: Future Virology Editorial Board . 2024-03-10 . Future Virology . en.
- Web site: Peter Openshaw . 2024-03-10 . scholar.google.com.
- Web site: Peter Openshaw . 2024-03-10 . www.imperial.ac.uk.
- Web site: 2019-05-30 . Professor Peter Openshaw elected as Senior Consul at Imperial . 2024-03-11 . Imperial News . en.
- Web site: Knighthoods for Chief Medical Officers in COVID Dominated New Year Honours . 2024-03-11 . Medscape UK . en.
- Web site: Working Together Task Group . 2024-03-11 . Imperial College London . en-GB.
- Web site: New and Emerging Respiratory Virus Threats Advisory Group. GOV.UK. en. 2020-03-20.
- Web site: Honours and Memberships - Peter Openshaw - Professor of Experimental Medicine . 2024-03-11 . www.imperial.ac.uk.
- Web site: Openshaw . Peter . 2017-10-04 . Vaccines are vital: there's never been a more exciting time to be a vaccinologist! . 2024-03-11 . Imperial Medicine Blog . en-GB.
- Web site: NIHR Senior Investigator awards for Imperial . 2024-03-11 . NIHR Imperial Biomedical Research Centre . en-GB.