Perisinusoidal space explained

Perisinusoidal space
Latin:spatium perisinusoideum
Location:Liver

The perisinusoidal space (or space of Disse) is a space between a hepatocyte, and a sinusoid in the liver. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the sinusoid endothelium facilitates this transport.[1] The perisinusoidal space also contains hepatic stellate cells (also known as Ito cells or lipocytes), which store vitamin A in characteristic lipid droplets.[2]

This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes such as bilirubin.

The Space of Disse is named for the German anatomist Joseph Disse (1852–1912).[3]

Pathophysiology

Fibrosis

Liver injury from a number of causes can activate the hepatic stellate cells into transdifferentiated and prolific myofibroblasts.[4] The myofibroblasts synthesize and secrete components of the extracellular matrix including collagen into the perisinusoidal space.[4] This in turn promotes the development of fibrosis, and continuing fibrosis is thought to be responsible for the development of cirrhosis, and liver cancer.[5]

References

  1. Book: Robbins, Stanley L. . Cotran, Ramzi S. . Kumar, Vinay . Collins, Tucker . Robbins pathologic basis of disease . Saunders . Philadelphia . 1999 . 0-7216-7335-X .
  2. Book: Kumar . Vinay . Abbas . Abul K. . Aster . Jon C. . Robbins . Stanley L. . Perkins . James A. . Robbins basic pathology . 2018 . Elsevier . Philadelphia, Pennsylvania . 9780323353175 . 637 . Tenth.
  3. Haubrich WS . Disse of the space of Disse . Gastroenterology . 127 . 6 . 1684 . 2004 . 15578505 . 10.1053/j.gastro.2004.10.021.
  4. Tacke . F . Weiskirchen . R . Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques. . Expert Review of Gastroenterology & Hepatology . February 2012 . 6 . 1 . 67–80 . 10.1586/egh.11.92 . 22149583.
  5. Cheng . S . Zou . Y . Zhang . M . Single-cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosis. . MedComm . October 2023 . 4 . 5 . e378 . 10.1002/mco2.378 . 37724132. 10505372 .

External links

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Perisinusoidal space".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.