| Parkers River | |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Massachusetts |
| Source1: | Long Pond |
| Source1 Location: | NW of West Yarmouth |
| Source1 Coordinates: | 41.6736°N -70.1872°W |
| Source1 Elevation: | 33feet |
| Mouth: | Atlantic Ocean |
| Mouth Location: | SE of West Yarmouth |
| Mouth Coordinates: | 41.6371°N -70.2214°W[1] |
| Mouth Elevation: | 0feet |
Parkers River is a river in Barnstable County, Massachusetts. It drains out of Long Pond in West Yarmouth, flows through Seine Pond, and empties into the Nantucket Sound southeast of West Yarmouth. Named for Isaiah Parker who lived on the west bank of the river.