| Native Name: | Departamento de Panamá |
| Conventional Long Name: | Panama Department |
| Common Name: | Panama |
| Subdivision: | Department |
| Nation: | Colombia |
| Event Start: | Regeneration |
| Year Start: | 1886 |
| Date Start: | 7 September |
| Event End: | Separation of Panama |
| Year End: | 1903 |
| Date End: | 8 November |
| P1: | Panama State |
| Flag P1: | Flag of Sovereign State of Panama.svg |
| S1: | Panama |
| Flag S1: | Flag of Panama (1903).svg |
| Image Map Caption: | Panama from 1886 to 1903 under Colombian rule. |
| Capital: | Panama City |
| Today: | Panama |
| Life Span: | 1886–1903 |
| Title Leader: | Governor |
| Government Type: | Departmental government |
Panama was one of the Departments of Colombia, created under the 1886 constitution. Its predecessor was Panama State of the Republic of New Granada (1855–1858), the Granadine Confederation (1858–1863) and United States of Colombia (1863–1886). In 1903, it achieved independence as the modern Republic of Panama with the concession of the Panama Canal Zone to the United States. Colombia did not formally recognize the sovereignty of Panama until 1909.
A previous incarnation of the Panama Department, also known as the Isthmus Department, was part of Gran Colombia from 1824 to 1831.