PRKD2 explained

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase C. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.^[3]

Further reading

• Sturany S, Van Lint J, Gilchrist A, etal . Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor. . J. Biol. Chem. . 277 . 33 . 29431–6 . 2002 . 12058027 . 10.1074/jbc.M200934200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Rey O, Yuan J, Rozengurt E . Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists. . Biochem. Biophys. Res. Commun. . 302 . 4 . 817–24 . 2003 . 12646243 . 10.1016/S0006-291X(03)00269-9 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Yeaman C, Ayala MI, Wright JR, etal . Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. . Nat. Cell Biol. . 6 . 2 . 106–12 . 2004 . 14743217 . 10.1038/ncb1090 . 3372901.
• Mihailovic T, Marx M, Auer A, etal . Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. . Cancer Res. . 64 . 24 . 8939–44 . 2005 . 15604256 . 10.1158/0008-5472.CAN-04-0981 . free .
• Parra M, Kasler H, McKinsey TA, etal . Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. . J. Biol. Chem. . 280 . 14 . 13762–70 . 2005 . 15623513 . 10.1074/jbc.M413396200 . free .
• Auer A, von Blume J, Sturany S, etal . Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling. . Mol. Biol. Cell . 16 . 9 . 4375–85 . 2006 . 15975900 . 10.1091/mbc.E05-03-0251 . 1196345 .
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells. . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Jackson LN, Li J, Chen LA, etal . Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells. . Biochem. Biophys. Res. Commun. . 348 . 3 . 945–9 . 2006 . 16899224 . 10.1016/j.bbrc.2006.07.142 . 2430871 .
• Mary Pat Moyer . Chiu TT, Leung WY, Moyer MP, etal . Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. . Am. J. Physiol., Cell Physiol. . 292 . 2 . C767–77 . 2007 . 16928771 . 10.1152/ajpcell.00308.2006 . 2220790 .
• Irie A, Harada K, Tsukamoto H, etal . Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. . Int. Immunol. . 18 . 12 . 1737–47 . 2007 . 17077180 . 10.1093/intimm/dxl108 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Kollers S, Musilova P, Rubes J, Rocha D . Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. . Anim. Genet. . 37 . 6 . 595–6 . 2007 . 17121608 . 10.1111/j.1365-2052.2006.01516.x .
• Wissing J, Jänsch L, Nimtz M, etal . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . free . 10033/19756 . free .

Notes and References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res . 10 . 10 . 1546–60 . Nov 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
2. Sturany S, Van Lint J, Muller F, Wilda M, Hameister H, Hocker M, Brey A, Gern U, Vandenheede J, Gress T, Adler G, Seufferlein T . Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases . J Biol Chem . 276 . 5 . 3310–8 . May 2001 . 11062248 . 10.1074/jbc.M008719200 . free .
3. Web site: Entrez Gene: PRKD2 protein kinase D2.