PPP3CB explained

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.^{[1] [2] [3]}

Further reading

• Chen MX, Chen YH, Cohen PT . Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. . FEBS Lett. . 306 . 1 . 54–8 . 1992 . 1321058 . 10.1016/0014-5793(92)80836-6 . 31397906 .
• McPartlin AE, Barker HM, Cohen PT . Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta. . Biochim. Biophys. Acta . 1088 . 2 . 308–10 . 1991 . 1848109 . 10.1016/0167-4781(91)90069-x.
• Guerini D, Klee CB . Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. . Proc. Natl. Acad. Sci. U.S.A. . 86 . 23 . 9183–7 . 1990 . 2556704 . 10.1073/pnas.86.23.9183 . 298458 . free .
• Shibasaki F, McKeon F . Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. . J. Cell Biol. . 131 . 3 . 735–43 . 1995 . 7593193 . 10.1083/jcb.131.3.735 . 2120616 .
• Muramatsu T, Kincaid RL . Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). . Biochim. Biophys. Acta . 1178 . 1 . 117–20 . 1993 . 8392375 . 10.1016/0167-4889(93)90117-8 .
• Kissinger CR, Parge HE, Knighton DR, etal . Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. . Nature . 378 . 6557 . 641–4 . 1996 . 8524402 . 10.1038/378641a0 . 1995Natur.378..641K . 4337105 .
• Wang MG, Yi H, Guerini D, etal . Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. . Cytogenet. Cell Genet. . 72 . 2–3 . 236–41 . 1997 . 8978785 . 10.1159/000134198 .
• Sun L, Youn HD, Loh C, etal . Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. . Immunity . 8 . 6 . 703–11 . 1998 . 9655484 . 10.1016/S1074-7613(00)80575-0 . free .
• Aramburu J, Garcia-Cózar F, Raghavan A, etal . Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. . Mol. Cell . 1 . 5 . 627–37 . 1998 . 9660947 . 10.1016/S1097-2765(00)80063-5 . free .
• Okamura H, Aramburu J, García-Rodríguez C, etal . Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. . Mol. Cell . 6 . 3 . 539–50 . 2000 . 11030334 . 10.1016/S1097-2765(00)00053-8 . free .
• Frey N, Richardson JA, Olson EN . Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14632–7 . 2001 . 11114196 . 10.1073/pnas.260501097 . 18970 . 2000PNAS...9714632F . free .
• Esau C, Boes M, Youn HD, etal . Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. . J. Exp. Med. . 194 . 10 . 1449–59 . 2001 . 11714752 . 10.1084/jem.194.10.1449 . 2193671 .
• Frey N, Olson EN . Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. . J. Biol. Chem. . 277 . 16 . 13998–4004 . 2002 . 11842093 . 10.1074/jbc.M200712200 . free .
• Banerjee A, Banks AS, Nawijn MC, etal . Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp. . J. Immunol. . 168 . 9 . 4277–81 . 2002 . 11970967 . 10.4049/jimmunol.168.9.4277. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E . Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. . Virology . 303 . 1 . 174–80 . 2003 . 12482669 . 10.1006/viro.2002.1676 . free .
• Genescà L, Aubareda A, Fuentes JJ, etal . Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. . Biochem. J. . 374 . Pt 2 . 567–75 . 2003 . 12809556 . 10.1042/BJ20030267 . 1223619 .
• Bell O, Gaberman E, Kilav R, etal . The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. . Mol. Endocrinol. . 19 . 2 . 516–26 . 2005 . 15514034 . 10.1210/me.2004-0108 . 27672093 .

Notes and References

1. Giri PR, Higuchi S, Kincaid RL . Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit . Biochem Biophys Res Commun . 181 . 1 . 252–8 . Jan 1992 . 1659808 . 10.1016/S0006-291X(05)81410-X .
2. Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB . Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase . DNA . 8 . 9 . 675–82 . Mar 1990 . 2558868 . 10.1089/dna.1.1989.8.675.
3. Web site: Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform.