POLE2 explained

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.^{[1] [2] [3]}

Interactions

POLE2 has been shown to interact with SAP18.^[4]

Further reading

• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Post SM, Tomkinson AE, Lee EY . Eva Y.-H. P. Lee . The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase ε . Nucleic Acids Res. . 31 . 19 . 5568–75 . 2003 . 14500819 . 206465 . 10.1093/nar/gkg765 .
• Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F . The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA . J. Biochem. . 131 . 3 . 307–11 . 2002 . 11872158 . 10.1093/oxfordjournals.jbchem.a003104 .
• Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE . E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2 . Nucleic Acids Res. . 29 . 13 . 2810–21 . 2001 . 11433027 . 55767 . 10.1093/nar/29.13.2810 .
• Li Y, Pursell ZF, Linn S . Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon . J. Biol. Chem. . 275 . 30 . 23247–52 . 2000 . 10801849 . 10.1074/jbc.M002548200 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase epsilon subunit 2 (POLE2)

Notes and References

1. Li Y, Asahara H, Patel VS, Zhou S, Linn S . Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon . J Biol Chem . 272 . 51 . 32337–44 . Jan 1998 . 9405441 . 10.1074/jbc.272.51.32337 . free .
2. Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE . The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon . Nucleic Acids Res . 26 . 3 . 730–4 . Mar 1998 . 9443964 . 147316 . 10.1093/nar/26.3.730 .
3. Web site: Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit).
4. Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F . The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA . J. Biochem. . 131 . 3 . 307–11 . Mar 2002 . 11872158 . 10.1093/oxfordjournals.jbchem.a003104 .