PLXNB2 explained

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.^{[1] [2] [3]}

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.^[4]

Further reading

• Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG . Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors . Cancer Lett. . 89 . 2 . 215–21 . 1995 . 7889532 . 10.1016/0304-3835(95)03690-X .
• Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ . An expression-independent catalog of genes from human chromosome 22 . Genome Res. . 5 . 3 . 214–24 . 1996 . 8593609 . 10.1101/gr.5.3.214 . free .
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L . Functional regulation of semaphorin receptors by proprotein convertases . J. Biol. Chem. . 278 . 12 . 10094–101 . 2003 . 12533544 . 10.1074/jbc.M210156200 . free .
• Oinuma I, Katoh H, Harada A, Negishi M . Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells . J. Biol. Chem. . 278 . 28 . 25671–7 . 2003 . 12730235 . 10.1074/jbc.M303047200 . free .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S . Interplay between scatter factor receptors and B plexins controls invasive growth . Oncogene . 23 . 30 . 5131–7 . 2004 . 15184888 . 10.1038/sj.onc.1207650 . free .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .

Notes and References

1. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM . Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates . Cell . 99 . 1 . 71–80 . Oct 1999 . 10520995 . 10.1016/S0092-8674(00)80063-X . free .
2. Perrot V, Vazquez-Prado J, Gutkind JS . Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF . J Biol Chem . 277 . 45 . 43115–20 . Nov 2002 . 12183458 . 10.1074/jbc.M206005200 . free .
3. Web site: Entrez Gene: PLXNB2 plexin B2.
4. Swiercz JM, Kuner R, Behrens J, Offermanns S . Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology . Neuron . 35 . 1 . 51–63 . Jul 2002 . 12123608 . 10.1016/S0896-6273(02)00750-X . free .