PLK3 explained

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.^{[1] [2]}

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.

Interactions

PLK3 has been shown to interact with:

• CDC25C,^[3]
• CHEK2,^[4] and
• P53.^{[4] [5]}

Further reading

• Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W . Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas . J. Biol. Chem. . 271 . 32 . 19402–8 . 1996 . 8702627 . 10.1074/jbc.271.32.19402 . free .
• Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H . Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 . Science . 277 . 5331 . 1501–5 . 1997 . 9278512 . 10.1126/science.277.5331.1501 .
• Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W . Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions . J. Biol. Chem. . 272 . 45 . 28646–51 . 1997 . 9353331 . 10.1074/jbc.272.45.28646 . free .
• Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D . The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity . EMBO J. . 18 . 20 . 5528–39 . 1999 . 10523297 . 1171621 . 10.1093/emboj/18.20.5528 .
• Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W . The physical association and phosphorylation of Cdc25C protein phosphatase by Prk . Oncogene . 18 . 44 . 6029–36 . 1999 . 10557092 . 10.1038/sj.onc.1202983 . free .
• Shieh SY, Ahn J, Tamai K, Taya Y, Prives C . The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites . Genes Dev. . 14 . 3 . 289–300 . 2000 . 10.1101/gad.14.3.289 . 10673501 . 316358 .
• Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P . PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer . Genes Chromosomes Cancer . 27 . 3 . 332–6 . 2000 . 10679924 . 10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K . 20642025 .
• Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ . Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro . Proc. Natl. Acad. Sci. U.S.A. . 97 . 19 . 10389–94 . 2000 . 10973490 . 27034 . 10.1073/pnas.190030497 . 2000PNAS...9710389M . free .
• Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K . Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages . Oncogene . 19 . 42 . 4832–9 . 2000 . 11039900 . 10.1038/sj.onc.1203845 . 25807289 .
• Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ . Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase . Nature . 411 . 6833 . 102–7 . 2001 . 11333986 . 10.1038/35075107 . 2001Natur.411..102B . 4410763 .
• Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W . Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway . J. Biol. Chem. . 276 . 46 . 43305–12 . 2001 . 11551930 . 10.1074/jbc.M106050200 . free .
• Latonen L, Taya Y, Laiho M . UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts . Oncogene . 20 . 46 . 6784–93 . 2001 . 11709713 . 10.1038/sj.onc.1204883 . free .
• Ahn JY, Li X, Davis HL, Canman CE . Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain . J. Biol. Chem. . 277 . 22 . 19389–95 . 2002 . 11901158 . 10.1074/jbc.M200822200 . free .
• Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM . The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase . Mol. Cell . 9 . 3 . 515–25 . 2002 . 11931760 . 10.1016/S1097-2765(02)00473-2 . free .
• Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W . Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity . Mol. Cell. Biol. . 22 . 10 . 3450–9 . 2002 . 11971976 . 133784 . 10.1128/MCB.22.10.3450-3459.2002 .
• Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ . Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways . Oncogene . 21 . 43 . 6633–40 . 2002 . 12242661 . 10.1038/sj.onc.1205850 . 24106070 .
• Tsvetkov L, Xu X, Li J, Stern DF . Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody . J. Biol. Chem. . 278 . 10 . 8468–75 . 2003 . 12493754 . 10.1074/jbc.M211202200 . free .
• Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W . Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2 . Cell Cycle . 1 . 6 . 424–9 . 2003 . 12548019 . 10.4161/cc.1.6.271 . free .
• Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ . Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation . Oncogene . 23 . 15 . 2658–63 . 2004 . 14968113 . 10.1038/sj.onc.1207425 . free .

Notes and References

1. Web site: Entrez Gene: PLK3 polo-like kinase 3 (Drosophila).
2. Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W . Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas . J. Biol. Chem. . 271 . 32 . 19402–8 . August 1996 . 8702627 . 10.1074/jbc.271.32.19402 . free .
3. Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W . The physical association and phosphorylation of Cdc25C protein phosphatase by Prk . Oncogene . 18 . 44 . 6029–36 . Oct 1999 . 10557092 . 10.1038/sj.onc.1202983 . free .
4. Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ . Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways . Oncogene . 21 . 43 . 6633–40 . Sep 2002 . 12242661 . 10.1038/sj.onc.1205850 . 24106070 .
5. Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W . Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway . J. Biol. Chem. . 276 . 46 . 43305–12 . Nov 2001 . 11551930 . 10.1074/jbc.M106050200 . free .