PLCD1 explained

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene.^{[1] [2]} PLCd1 is essential to maintain homeostasis of the skin.

See also

Phospholipase C

Further reading

• Yagisawa H . Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+. . J. Cell. Biochem. . 97 . 2 . 233–43 . 2006 . 16240320 . 10.1002/jcb.20677 . 84240929 . free .
• Cefai D, Debre P, Kaczorek M, etal . Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. . J. Clin. Invest. . 86 . 6 . 2117–24 . 1991 . 1979339 . 10.1172/JCI114950 . 329852 .
• Zauli G, Previati M, Caramelli E, etal . Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. . Eur. J. Immunol. . 25 . 9 . 2695–700 . 1995 . 7589147 . 10.1002/eji.1830250944 . 20562627 .
• Cheng HF, Jiang MJ, Chen CL, etal . Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. . J. Biol. Chem. . 270 . 10 . 5495–505 . 1995 . 7890667 . 10.1074/jbc.270.10.5495 . free .
• Ghosh S, Pawelczyk T, Lowenstein JM . Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. . Protein Expr. Purif. . 9 . 2 . 262–78 . 1997 . 9056492 . 10.1006/prep.1996.0682 .
• Chen P, Mayne M, Power C, Nath A . The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. . J. Biol. Chem. . 272 . 36 . 22385–8 . 1997 . 9278385 . 10.1074/jbc.272.36.22385 . free .
• Park ES, Won JH, Han KJ, etal . Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector. . Biochem. J. . 331 . 1. 283–9 . 1998 . 9512491 . 10.1042/bj3310283. 1219350 .
• Shimohama S, Kamiya S, Fujii M, etal . Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function. . Biochem. Biophys. Res. Commun. . 245 . 3 . 722–8 . 1998 . 9588182 . 10.1006/bbrc.1998.8307 .
• Mayne M, Bratanich AC, Chen P, etal . HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. . Neuroimmunomodulation . 5 . 3–4 . 184–92 . 1998 . 9730685 . 10.1159/000026336 . 19529677 .
• Haughey NJ, Holden CP, Nath A, Geiger JD . Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. . J. Neurochem. . 73 . 4 . 1363–74 . 1999 . 10501179 . 10.1046/j.1471-4159.1999.0731363.x . 25410140 . free .
• Mayne M, Holden CP, Nath A, Geiger JD . Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. . J. Immunol. . 164 . 12 . 6538–42 . 2000 . 10843712 . 10.4049/jimmunol.164.12.6538. free .
• Nash MS, Young KW, Willars GB, etal . Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation. . Biochem. J. . 356 . Pt 1 . 137–42 . 2001 . 11336645 . 10.1042/0264-6021:3560137 . 1221821 .
• Ananthanarayanan B, Das S, Rhee SG, etal . Membrane targeting of C2 domains of phospholipase C-delta isoforms. . J. Biol. Chem. . 277 . 5 . 3568–75 . 2002 . 11706040 . 10.1074/jbc.M109705200 . free .
• Keshamouni VG, Mattingly RR, Reddy KB . Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. . J. Biol. Chem. . 277 . 25 . 22558–65 . 2002 . 11960991 . 10.1074/jbc.M202351200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E . Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. . Virology . 303 . 1 . 174–80 . 2003 . 12482669 . 10.1006/viro.2002.1676 . free .
• Guo Y, Philip F, Scarlata S . The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. . J. Biol. Chem. . 278 . 32 . 29995–30004 . 2003 . 12761218 . 10.1074/jbc.M301438200 . free .
• Caprini M, Gomis A, Cabedo H, etal . GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity. . EMBO J. . 22 . 12 . 3004–14 . 2003 . 12805215 . 10.1093/emboj/cdg294 . 162146 .
• Kim JY, Kim H, Lee SG, etal . Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site. . Biochem. Biophys. Res. Commun. . 310 . 3 . 904–9 . 2003 . 14550290 . 10.1016/j.bbrc.2003.09.100 .

External links

• WikiGenes entry for PLCD1

Notes and References

1. Ishikawa S, Takahashi T, Ogawa M, Nakamura Y . Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22→p21.3 . Cytogenet Cell Genet . 78 . 1 . 58–60 . Nov 1997 . 9345909 . 10.1159/000134629 .
2. Web site: Entrez Gene: PLCD1 phospholipase C, delta 1.