PIK3C3 explained

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene.^{[1] [2]} It's a class III phosphoinositide 3-kinase.

Further reading

• Lee C, Liu QH, Tomkowicz B, etal . Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. . J. Leukoc. Biol. . 74 . 5 . 676–82 . 2004 . 12960231 . 10.1189/jlb.0503206 . 11362623 . free .
• Vogel LB, Fujita DJ . The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes. . Mol. Cell. Biol. . 13 . 12 . 7408–17 . 1994 . 7504174 . 10.1128/mcb.13.12.7408. 364812 .
• Milani D, Mazzoni M, Borgatti P, etal . Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. . J. Biol. Chem. . 271 . 38 . 22961–4 . 1996 . 8798481 . 10.1074/jbc.271.38.22961 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Panaretou C, Domin J, Cockcroft S, Waterfield MD . Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex. . J. Biol. Chem. . 272 . 4 . 2477–85 . 1997 . 8999962 . 10.1074/jbc.272.4.2477 . free .
• Mazerolles F, Barbat C, Fischer A . Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. . Eur. J. Immunol. . 27 . 9 . 2457–65 . 1997 . 9341793 . 10.1002/eji.1830270946 . 33397908 .
• Borgatti P, Zauli G, Colamussi ML, etal . Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. . Eur. J. Immunol. . 27 . 11 . 2805–11 . 1998 . 9394803 . 10.1002/eji.1830271110 . 6303471 .
• Borgatti P, Zauli G, Cantley LC, Capitani S . Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. . Biochem. Biophys. Res. Commun. . 242 . 2 . 332–7 . 1998 . 9446795 . 10.1006/bbrc.1997.7877 .
• Milani D, Mazzoni M, Zauli G, etal . HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. . AIDS . 12 . 11 . 1275–84 . 1998 . 9708406 . 10.1097/00002030-199811000-00008 . 25758704 . free .
• Jauliac S, Mazerolles F, Jabado N, etal . Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. . Eur. J. Immunol. . 28 . 10 . 3183–91 . 1998 . 9808187 . 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A . free .
• Park IW, Wang JF, Groopman JE . HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. . Blood . 97 . 2 . 352–8 . 2001 . 11154208 . 10.1182/blood.V97.2.352 . free .
• Zauli G, Milani D, Mirandola P, etal . HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. . FASEB J. . 15 . 2 . 483–91 . 2001 . 11156964 . 10.1096/fj.00-0354com . free . 26315564 .
• Deregibus MC, Cantaluppi V, Doublier S, etal . HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. . J. Biol. Chem. . 277 . 28 . 25195–202 . 2002 . 11994280 . 10.1074/jbc.M200921200 . free .
• Cook JA, August A, Henderson AJ . Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. . J. Immunol. . 169 . 1 . 254–60 . 2002 . 12077252 . 10.4049/jimmunol.169.1.254. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• François F, Klotman ME . Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. . J. Virol. . 77 . 4 . 2539–49 . 2003 . 12551992 . 10.1128/JVI.77.4.2539-2549.2003 . 141101 .
• Vergne I, Chua J, Deretic V . Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade. . J. Exp. Med. . 198 . 4 . 653–9 . 2003 . 12925680 . 10.1084/jem.20030527 . 2194170 .
• Khan NA, Di Cello F, Nath A, Kim KS . Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells. . J. Neurovirol. . 9 . 6 . 584–93 . 2004 . 14602571 . 10.1080/jnv.9.6.584.593 .

Notes and References

1. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD . A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system . EMBO J . 14 . 14 . 3339–48 . Sep 1995 . 7628435 . 394401 . 10.1002/j.1460-2075.1995.tb07340.x.
2. Web site: Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3.