PIGQ explained

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.^{[1] [2] [3]}

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).

Interactions

PIGQ has been shown to interact with PIGH, PIGA^[1] and PIGC.^[1]

Further reading

• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Martin J, Han C, Gordon LA, etal . The sequence and analysis of duplication-rich human chromosome 16 . Nature . 432 . 7020 . 988–94 . 2005 . 15616553 . 10.1038/nature03187 . 2004Natur.432..988M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tiede A, Daniels RJ, Higgs DR, etal . The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis . Gene . 271 . 2 . 247–54 . 2001 . 11418246 . 10.1016/S0378-1119(01)00510-8 .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Watanabe R, Murakami Y, Marmor MD, etal . Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2 . EMBO J. . 19 . 16 . 4402–11 . 2000 . 10944123 . 10.1093/emboj/19.16.4402 . 302040 .
• Hong Y, Ohishi K, Watanabe R, etal . GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis . J. Biol. Chem. . 274 . 26 . 18582–8 . 1999 . 10373468 . 10.1074/jbc.274.26.18582 . free .
• Watanabe R, Kinoshita T, Masaki R, etal . PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum . J. Biol. Chem. . 271 . 43 . 26868–75 . 1996 . 8900170 . 10.1074/jbc.271.43.26868 . free .

Notes and References

1. Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T . The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 . EMBO J . 17 . 4 . 877–85 . Mar 1998 . 9463366 . 1170437 . 10.1093/emboj/17.4.877 .
2. Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE . Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants . Biochem J . 334 . 3. 609–16 . Nov 1998 . 9729469 . 1219730 . 10.1042/bj3340609.
3. Web site: Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q.