PIGF explained
Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.[1] [2] [3]
Function
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.[3]
See also
Further reading
- Kinoshita T, Takahashi M, Inoue N, Miyata T, Takeda J . Expression cloning of genes for GPI-anchor biosynthesis . Brazilian Journal of Medical and Biological Research . 27 . 2 . 127–132 . Feb 1994 . 8081220 .
- Hong Y, Maeda Y, Watanabe R, Inoue N, Ohishi K, Kinoshita T . Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol . The Journal of Biological Chemistry . 275 . 27 . 20911–20919 . Jul 2000 . 10781593 . 10.1074/jbc.M001913200 . free.
- Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y, Kinoshita T . GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol . The Journal of Biological Chemistry . 280 . 10 . 9728–9734 . Mar 2005 . 15632136 . 10.1074/jbc.M413755200 . free .
- Li W, Shen W, Gill R, Corbly A, Jones B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K, Westmore M, Hanson J, Chen YF, Simons M, Singh J . High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb . Circulation . 113 . 20 . 2445–2453 . May 2006 . 16702473 . 10.1161/CIRCULATIONAHA.105.586818 . free .
- Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC . Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality . The Journal of Experimental Medicine . 203 . 6 . 1447–1458 . Jun 2006 . 16702604 . 2118329 . 10.1084/jem.20060375 .
- Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M . Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation . Arteriosclerosis, Thrombosis, and Vascular Biology . 26 . 9 . 2019–2026 . Sep 2006 . 16794222 . 10.1161/01.ATV.0000233336.53574.a1 . free .
- Mohammed KA, Nasreen N, Tepper RS, Antony VB . Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release . American Journal of Physiology. Lung Cellular and Molecular Physiology . 292 . 2 . L559–566 . Feb 2007 . 17028267 . 10.1152/ajplung.00075.2006 .
Notes and References
- Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T . Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF . Genomics . 29 . 3 . 804–807 . Oct 1995 . 8575782 . 10.1006/geno.1995.9929 .
- Inoue N, Kinoshita T, Orii T, Takeda J . Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy . The Journal of Biological Chemistry . 268 . 10 . 6882–6885 . Apr 1993 . 10.1016/S0021-9258(18)53122-7 . 8463218 . free .
- Web site: Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F.
