PICK1 explained

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.^{[1] [2]}

Function

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

PICK1 has been shown to interact with:

• ACCN2,^{[4] [5]}
• BNC1,^[5]
• Dopamine transporter,^[6]
• GRIA2,
• GRIA3,
• GRIA4,
• GRIK1,^[7]
• GRIK2,^[7]
• GRIK3,
• HER2/neu,^[8]
• Metabotropic glutamate receptor 3,^[9] and
• Metabotropic glutamate receptor 7.^[10]

Further reading

• Collingridge GL, Isaac JT . Functional roles of protein interactions with AMPA and kainate receptors . Neurosci. Res. . 47 . 1 . 3–15 . 2003 . 12941441 . 10.1016/S0168-0102(03)00160-3 . 22572652 .
• Xu J, Xia J . Structure and function of PICK1 . Neurosignals . 15 . 4 . 190–201 . 2006 . 17215589 . 10.1159/000098482 . free .
• Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN . PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system . J. Cell Biol. . 128 . 3 . 263–71 . 1995 . 7844141 . 2120344 . 10.1083/jcb.128.3.263 .
• Staudinger J, Lu J, Olson EN . Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha . J. Biol. Chem. . 272 . 51 . 32019–24 . 1998 . 9405395 . 10.1074/jbc.272.51.32019 . free .
• Xia J, Zhang X, Staudinger J, Huganir RL . Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1 . Neuron . 22 . 1 . 179–87 . 1999 . 10027300 . 10.1016/S0896-6273(00)80689-3 . free .
• Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD . PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands . Neuron . 21 . 6 . 1453–63 . 1999 . 9883737 . 10.1016/S0896-6273(00)80663-7 . free .
• Takeya R, Takeshige K, Sumimoto H . Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors . Biochem. Biophys. Res. Commun. . 267 . 1 . 149–55 . 2000 . 10623590 . 10.1006/bbrc.1999.1932 .
• Cowan CA, Yokoyama N, Bianchi LM, Henkemeyer M, Fritzsch B . EphB2 guides axons at the midline and is necessary for normal vestibular function . Neuron . 26 . 2 . 417–30 . 2000 . 10839360 . 10.1016/S0896-6273(00)81174-5 . free .
• Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S . PICK1 interacts with and regulates PKC phosphorylation of mGLUR7 . J. Neurosci. . 20 . 19 . 7252–7 . 2001 . 11007882 . 10.1523/JNEUROSCI.20-19-07252.2000. Metabotropic glutamate receptor 7 . 6772771 . free .
• Lin WJ, Chang YF, Wang WL, Huang CY . Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1 . Biochem. J. . 354 . Pt 3 . 635–43 . 2001 . 11237868 . 1221695 . 10.1042/0264-6021:3540635 .
• Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP . The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins . J. Biol. Chem. . 276 . 18 . 15256–63 . 2001 . 11278603 . 10.1074/jbc.M010032200 . free .
• Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG . Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1 . Neuron . 30 . 1 . 121–34 . 2001 . 11343649 . 10.1016/S0896-6273(01)00267-7 . free .
• Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O . The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering . Mol. Pharmacol. . 60 . 5 . 916–23 . 2001 . 11641419 . 10.1124/mol.60.5.916. 9613515 .
• Duggan A, Garcia-Anoveros J, Corey DP . The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons . J. Biol. Chem. . 277 . 7 . 5203–8 . 2002 . 11739374 . 10.1074/jbc.M104748200 . free .
• Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ . Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel) . Biochem. J. . 361 . Pt 3 . 443–50 . 2002 . 11802773 . 1222326 . 10.1042/0264-6021:3610443 .
• Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK . The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs . J. Biol. Chem. . 277 . 18 . 15221–4 . 2002 . 11891216 . 10.1074/jbc.C200112200 . free .
• Perroy J, El Far O, Bertaso F, Pin JP, Betz H, Bockaert J, Fagni L . PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7 . EMBO J. . 21 . 12 . 2990–9 . 2002 . 12065412 . 126066 . 10.1093/emboj/cdf313 .
• Jansen AM, Nässel DR, Madsen KL, Jung AG, Gether U, Kjaerulff O . PICK1 expression in the Drosophila nervous system primarily occurs in the nervous system . J. Comp. Neurol. . 517 . 3 . 313–322 . 2009 . 19757495 . 10.1002/cne.22155 . 205680305 . free .

External links

• Genecards
• MGI

Notes and References

1. Dev KK, Nishimune A, Henley JM, Nakanishi S . The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits . Neuropharmacology . 38 . 5 . 635–44 . July 1999 . 10340301 . 10.1016/S0028-3908(98)00230-5 . 20472140 .
2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . December 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
3. Web site: Entrez Gene: PICK1 protein interacting with PRKCA 1.
4. Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ . cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1 . Proc. Natl. Acad. Sci. U.S.A. . 100 . 4 . 2029–34 . February 2003 . 12578970 . 149953 . 10.1073/pnas.252782799 . free . 2003PNAS..100.2029L .
5. Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ . Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel) . Biochem. J. . 361 . Pt 3 . 443–50 . February 2002 . 11802773 . 1222326 . 10.1042/0264-6021:3610443.
6. Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG . Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1 . Neuron . 30 . 1 . 121–34 . April 2001 . 11343649 . 10.1016/s0896-6273(01)00267-7. free .
7. Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V . Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP . Neuron . 37 . 4 . 625–38 . February 2003 . 12597860 . 3314502 . 10.1016/s0896-6273(02)01191-1.
8. Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP . The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins . J. Biol. Chem. . 276 . 18 . 15256–63 . May 2001 . 11278603 . 10.1074/jbc.M010032200 . free .
9. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK . The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs . J. Biol. Chem. . 277 . 18 . 15221–4 . May 2002 . 11891216 . 10.1074/jbc.C200112200 . free .
10. Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S . PICK1 interacts with and regulates PKC phosphorylation of mGLUR7 . J. Neurosci. . 20 . 19 . 7252–7 . October 2000 . 11007882 . 6772771 . 10.1523/JNEUROSCI.20-19-07252.2000.