PDE1B explained

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^{[1] [2] [3]}

Further reading

• Repaske DR, Swinnen JV, Jin SL, etal . A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase . J. Biol. Chem. . 267 . 26 . 18683–8 . 1992 . 10.1016/S0021-9258(19)37015-2 . 1326532 . free .
• Spence S, Rena G, Sullivan M, etal . Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase . Biochem. J. . 321 (Pt 1) . Pt 1. 157–63 . 1997 . 9003415 . 10.1042/bj3210157. 1218050 .
• Zauli G, Milani D, Mirandola P, etal . HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway . FASEB J. . 15 . 2 . 483–91 . 2001 . 11156964 . 10.1096/fj.00-0354com . free . 26315564 .
• Fidock M, Miller M, Lanfear J . Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants . Cell. Signal. . 14 . 1 . 53–60 . 2002 . 11747989 . 10.1016/S0898-6568(01)00207-8 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Bender AT, Ostenson CL, Wang EH, Beavo JA . Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation . Proc. Natl. Acad. Sci. U.S.A. . 102 . 2 . 497–502 . 2005 . 15625104 . 10.1073/pnas.0408535102 . 544304 . 2005PNAS..102..497B . free .
• Bender AT, Beavo JA . PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte . Proc. Natl. Acad. Sci. U.S.A. . 103 . 2 . 460–5 . 2006 . 16407168 . 10.1073/pnas.0509972102 . 1326187 . 2006PNAS..103..460B . free .

Notes and References

1. Jiang X, Li J, Paskind M, Epstein PM . Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells . Proc Natl Acad Sci U S A . 93 . 20 . 11236–41 . Nov 1996 . 8855339 . 1074519 . 10.1073/pnas.93.20.11236 . 1996PNAS...9311236J . free .
2. Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R . Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1 . Cell Signal . 9 . 7 . 519–29 . Feb 1998 . 9419816 . 10.1016/S0898-6568(97)00046-6 .
3. Web site: Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent.