PCYT1A explained

Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene.^{[1] [2]}

Further reading

• Hunt AN, Normand CS, Postle AD . CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin. . Biochim. Biophys. Acta . 1043 . 1 . 19–26 . 1990 . 2155660 . 10.1016/0005-2760(90)90105-7.
• Vance JE, Vance DE . Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion? . J. Biol. Chem. . 263 . 12 . 5898–909 . 1988 . 10.1016/S0021-9258(18)60650-7 . 2833521 . free .
• Weinhold PA, Feldman DA . Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein. . Arch. Biochem. Biophys. . 318 . 1 . 147–56 . 1995 . 7726555 . 10.1006/abbi.1995.1215 .
• Johnson JE, Cornell RB . Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase. . Biochemistry . 33 . 14 . 4327–35 . 1994 . 8155650 . 10.1021/bi00180a029 .
• Dunne SJ, Cornell RB, Johnson JE, etal . Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase. . Biochemistry . 35 . 37 . 11975–84 . 1996 . 8810902 . 10.1021/bi960821+.
• Arnold RS, DePaoli-Roach AA, Cornell RB . Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes. . Biochemistry . 36 . 20 . 6149–56 . 1997 . 9166786 . 10.1021/bi970023z .
• Yang J, Wang J, Tseu I, etal . Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions. . 325 . Biochem. J. . (Pt 1) . 29–38 . 1997 . Pt 1 . 9224626 . 10.1042/bj3250029. 1218525 .
• Lykidis A, Baburina I, Jackowski S . Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. . J. Biol. Chem. . 274 . 38 . 26992–7001 . 1999 . 10480912 . 10.1074/jbc.274.38.26992 . free .
• Lagace TA, Miller JR, Ridgway ND . Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. . Mol. Cell. Biol. . 22 . 13 . 4851–62 . 2002 . 12052891 . 10.1128/MCB.22.13.4851-4862.2002 . 133913 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Guenther MG, Yu J, Kao GD, etal . Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. . Genes Dev. . 16 . 24 . 3130–5 . 2003 . 12502735 . 10.1101/gad.1037502 . 187500 .
• Xie M, Smith JL, Ding Z, etal . Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase. . J. Biol. Chem. . 279 . 27 . 28817–25 . 2004 . 15069071 . 10.1074/jbc.M403311200 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Enaw JO, Zhu H, Yang W, etal . CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. . BMC Medicine . 4. 36 . 2007 . 17184542 . 10.1186/1741-7015-4-36 . 1770928 . free .

Notes and References

1. Kalmar GB, Kay RJ, LaChance AC, Cornell RB . Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase . Biochim Biophys Acta . 1219 . 2 . 328–34 . Nov 1994 . 7918629 . 10.1016/0167-4781(94)90056-6.
2. Web site: Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha.