PCTK3 explained

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the CDK18 gene.^{[1] [2]}

Further reading

• Meyerson M, Enders GH, Wu CL, etal . A family of human cdc2-related protein kinases. . EMBO J. . 11 . 8 . 2909–17 . 1992 . 1639063 . 10.1002/j.1460-2075.1992.tb05360.x. 556772 .
• Okuda T, Valentine VA, Shapiro DN, Downing JR . Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. . Genomics . 21 . 1 . 217–21 . 1994 . 8088790 . 10.1006/geno.1994.1245 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Herskovits AZ, Davies P . Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. . Gene . 328 . 59–67 . 2004 . 15019984 . 10.1016/j.gene.2003.12.011 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Palmer KJ, Konkel JE, Stephens DJ . PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. . J. Cell Sci. . 118 . Pt 17 . 3839–47 . 2005 . 16091426 . 10.1242/jcs.02496 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Herskovits AZ, Davies P . The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. . Neurobiol. Dis. . 23 . 2 . 398–408 . 2006 . 16766195 . 10.1016/j.nbd.2006.04.004 . 39038607 .
• Wissing J, Jänsch L, Nimtz M, etal . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . free . 10033/19756 . free .

Notes and References

1. Okuda T, Cleveland JL, Downing JR . PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family . Oncogene . 7 . 11 . 2249–58 . Dec 1992 . 1437147 .
2. Web site: Entrez Gene: PCTK3 PCTAIRE protein kinase 3.