PCTK2 explained

Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the CDK17 gene.^{[1] [2]}

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to rat protein which is thought to play a role in terminally differentiated neurons.

Further reading

• Meyerson M . A family of human cdc2-related protein kinases . EMBO J. . 11 . 8 . 2909–17 . 1992 . 1639063 . 10.1002/j.1460-2075.1992.tb05360.x. 556772 . Enders GH . Wu CL . Su . LK . Gorka . C . Nelson . C . Harlow . E . Tsai . LH .
• Hirose T . Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain . Eur. J. Biochem. . 267 . 7 . 2113–21 . 2000 . 10727952 . 10.1046/j.1432-1327.2000.01218.x . Kawabuchi M . Tamaru T . Okumura . Nobuaki . Nagai . Katsuya . Okada . Masato .
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M . ik3-1/Cables is associated with Trap and Pctaire2 . Biochem. Biophys. Res. Commun. . 286 . 5 . 1045–50 . 2001 . 11527406 . 10.1006/bbrc.2001.5493 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Conte N . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . 2003 . 14603251 . 10.1038/sj.onc.1206972 . Delaval B . Ginestier C . Ferrand . Alexia . Isnardon . Daniel . Larroque . Christian . Prigent . Claude . Séraphin . Bertrand . Jacquemier . Jocelyne . 10536264 .
• Jin J . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . Smith FD . Stark C . Wells . Clark D. . Fawcett . James P. . Kulkarni . Sarang . Metalnikov . Pavel . O'Donnell . Paul . Taylor . Paul . 2371325 . free . 2004CBio...14.1436J .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Barrios-Rodiles M . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . Brown KR . Ozdamar B . Bose . R . Liu . Z . Donovan . RS . Shinjo . F . Liu . Y . Dembowy . J . 2005Sci...307.1621B . 39457788 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Wissing J . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . Jänsch L . Nimtz M . Dieterich . G. . Hornberger . R. . Keri . G. . Wehland . J. . Daub . H. . free . 10033/19756 . free .

Notes and References

1. Hirose T, Tamaru T, Okumura N, Nagai K, Okada M . PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons . Eur J Biochem . 249 . 2 . 481–8 . Dec 1997 . 9370357 . 10.1111/j.1432-1033.1997.t01-1-00481.x .
2. Web site: Entrez Gene: PCTK2 PCTAIRE protein kinase 2.