PCDH12 explained

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.^{[1] [2] [3]}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth.

Further reading

• Yagi T, Takeichi M . Cadherin superfamily genes: functions, genomic organization, and neurologic diversity . Genes Dev. . 14 . 10 . 1169–80 . 2000 . 10817752 . 10.1101/gad.14.10.1169. 44844497 . free .
• Nollet F, Kools P, van Roy F . Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members . J. Mol. Biol. . 299 . 3 . 551–72 . 2000 . 10835267 . 10.1006/jmbi.2000.3777 .
• Telo' P, Breviario F, Huber P, etal . Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells . J. Biol. Chem. . 273 . 28 . 17565–72 . 1998 . 9651350 . 10.1074/jbc.273.28.17565 . 25010153 . free .
• Ludwig D, Lorenz J, Dejana E, etal . cDNA cloning, chromosomal mapping, and expression analysis of human VE-Cadherin-2 . Mamm. Genome . 11 . 11 . 1030–3 . 2001 . 11063261 . 10.1007/s003350010186 . 35069268 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . 21903526 . free .

Notes and References

1. Wu Q, Maniatis T . Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes . Proc Natl Acad Sci U S A . 97 . 7 . 3124–9 . Apr 2000 . 10716726 . 16203 . 10.1073/pnas.060027397 . free .
2. Wu Q, Maniatis T . A striking organization of a large family of human neural cadherin-like cell adhesion genes . Cell . 97 . 6 . 779–90 . Jul 1999 . 10380929 . 10.1016/S0092-8674(00)80789-8 . 6014717 . free .
3. Web site: Entrez Gene: PCDH12 protocadherin 12.