PARG explained

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.^{[1] [2] [3]}

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.^[4]

Further reading

• Affar . E. B. . Germain . M. . Winstall . E. . Vodenicharov . M. . Shah . R. G. . Salvesen . G. S. . Poirier . G. G. . 10.1074/jbc.M007269200 . Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis . Journal of Biological Chemistry . 276 . 4 . 2935–2942 . 2000 . 11053413. free .
• Ohashi . S. . Kanai . M. . Hanai . S. . Uchiumi . F. . Maruta . H. . Tanuma . S. . Miwa . M. . Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells . Biochemical and Biophysical Research Communications . 307 . 4 . 915–921 . 2003 . 12878198 . 10.1016/S0006-291X(03)01272-5.
• Meyer . R. G. . Meyer-Ficca . M. L. . Jacobson . E. L. . Jacobson . M. K. . Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23) . Gene . 314 . 181–190 . 2003 . 14527731 . 10.1016/S0378-1119(03)00738-8.
• Golovanov . A. P. . Barillà . D. . Golovanova . M. . Hayes . F. . Lian . L. Y. . ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure . Molecular Microbiology . 50 . 4 . 1141–1153 . 2003 . 14622405 . 10.1046/j.1365-2958.2003.03750.x. 45704180 .
• Keil . C. . Petermann . E. . Oei . S. L. . 10.1016/j.abb.2004.02.024 . Tannins elevate the level of poly(ADP–ribose) in HeLa cell extracts . Archives of Biochemistry and Biophysics . 425 . 1 . 115–121 . 2004 . 15081900.
• Meyer-Ficca . M. L. . Meyer . R. G. . Coyle . D. L. . Jacobson . E. L. . Jacobson . M. K. . 10.1016/j.yexcr.2004.03.050 . Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments . Experimental Cell Research . 297 . 2 . 521–532 . 2004 . 15212953.
• Putt . K. S. . Hergenrother . P. J. . 10.1016/j.ab.2004.04.032 . A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation . Analytical Biochemistry . 333 . 2 . 256–264 . 2004 . 15450800.
• Bonicalzi . M. -E. . Haince . J. -F. . Droit . A. . Poirier . G. G. . Poly-ADP-ribosylation in health and disease . 10.1007/s00018-004-4505-1 . Cellular and Molecular Life Sciences . 62 . 7–8 . 739–750 . 2005 . 15868399.
• Bonicalzi . M. È. . Gagné . J. P. . Gagné . P. . Ouellet . M. È. . Hendzel . M. J. . Poirier . G. G. . Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles . 10.1042/BJ20050792 . Biochemical Journal . 392 . 3 . 499–509 . 1316289 . 2005 . 16117724.

Notes and References

1. Web site: Entrez Gene: Poly (ADP-ribose) glycohydrolase. 2011-11-08 .
2. Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK . Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase . J. Biol. Chem. . 272 . 18 . 11895–901 . May 1997 . 9115250 . 10.1074/jbc.272.18.11895. free .
3. Amé JC, Apiou F, Jacobson EL, Jacobson MK . Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization . Cytogenet. Cell Genet. . 85 . 3–4 . 269–70 . 1999 . 10449915 . 10.1159/000015310. 42156664 .
4. Web site: Entrez Gene: Poly (ADP-ribose) glycohydrolase. 2011-11-08 .