P2RY4 explained

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.^{[1] [2]}

The product of this gene, P2Y₄, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.^[2]

See also

• P2Y receptor

Further reading

• Nguyen T, Erb L, Weisman GA, etal . Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. . J. Biol. Chem. . 270 . 52 . 30845–8 . 1996 . 8537335 . 10.1074/jbc.270.52.30845 . free .
• Stam NJ, Klomp J, Van de Heuvel N, Olijve W . Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. . FEBS Lett. . 384 . 3 . 260–4 . 1996 . 8617367 . 10.1016/0014-5793(96)00321-3 . 20644988 . free .
• Nicholas RA, Watt WC, Lazarowski ER, etal . Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. . Mol. Pharmacol. . 50 . 2 . 224–9 . 1996 . 8700127 .
• Maier R, Glatz A, Mosbacher J, Bilbe G . Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. . Biochem. Biophys. Res. Commun. . 237 . 2 . 297–302 . 1997 . 9268704 . 10.1006/bbrc.1997.7135 .
• Jin J, Dasari VR, Sistare FD, Kunapuli SP . Distribution of P2Y receptor subtypes on haematopoietic cells. . Br. J. Pharmacol. . 123 . 5 . 789–94 . 1998 . 9535005 . 10.1038/sj.bjp.0701665 . 1565225 .
• Brinson AE, Harden TK . Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. . J. Biol. Chem. . 276 . 15 . 11939–48 . 2001 . 11114308 . 10.1074/jbc.M009909200 . free .
• Suarez-Huerta N, Pouillon V, Boeynaems J, Robaye B . Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. . Eur. J. Pharmacol. . 416 . 3 . 197–202 . 2001 . 11290369 . 10.1016/S0014-2999(01)00875-5 .
• Moore DJ, Chambers JK, Wahlin JP, etal . Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. . Biochim. Biophys. Acta . 1521 . 1–3 . 107–19 . 2001 . 11690642 . 10.1016/S0167-4781(01)00291-3.
• Idzko M, Dichmann S, Ferrari D, etal . Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. . Blood . 100 . 3 . 925–32 . 2002 . 12130504 . 10.1182/blood.V100.3.925 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR . Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. . J. Invest. Dermatol. . 120 . 3 . 440–7 . 2003 . 12603858 . 10.1046/j.1523-1747.2003.12050.x . free .
• Kim SG, Soltysiak KA, Gao ZG, etal . Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors. . Biochem. Pharmacol. . 65 . 6 . 923–31 . 2003 . 12623123 . 10.1016/S0006-2952(02)01614-3 . 3402349.
• Herold CL, Qi AD, Harden TK, Nicholas RA . Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop. . J. Biol. Chem. . 279 . 12 . 11456–64 . 2004 . 14670966 . 10.1074/jbc.M301734200 . 1821344 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Cavaliere F, Nestola V, Amadio S, etal . The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. . Neurobiol. Dis. . 18 . 1 . 100–9 . 2005 . 15649700 . 10.1016/j.nbd.2004.09.001 . 12915637 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome. . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .

External links

• Web site: P2Y Receptors: P2Y₄ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303204436/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2396 . dead .

Notes and References

1. Communi D, Pirotton S, Parmentier M, Boeynaems JM . Cloning and functional expression of a human uridine nucleotide receptor . J Biol Chem . 270 . 52 . 30849–52 . Feb 1996 . 8537336 . 10.1074/jbc.270.52.30849 . free .
2. Web site: Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4.