P2RY14 explained

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.^[1]

The product of this gene, P2Y₁₄ belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.

See also

• P2Y receptor

Further reading

• Gerard C, Gerard NP . C5A anaphylatoxin and its seven transmembrane-segment receptor . Annu. Rev. Immunol. . 12 . 775–808 . 1994 . 8011297 . 10.1146/annurev.iy.12.040194.004015 .
• Müller CE . P2-pyrimidinergic receptors and their ligands . Curr. Pharm. Des. . 8 . 26 . 2353–2369 . 2003 . 12369950 . 10.2174/1381612023392937 .
• Abbracchio MP, Boeynaems JM, Barnard EA, etal . Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family . Trends Pharmacol. Sci. . 24 . 2 . 52–55 . 2003 . 12559763 . 10.1016/S0165-6147(02)00038-X . 8653507 .
• von Kügelgen I . Pharmacological profiles of cloned mammalian P2Y-receptor subtypes . Pharmacol. Ther. . 110 . 3 . 415–432 . 2006 . 16257449 . 10.1016/j.pharmthera.2005.08.014 .
• Brunschweiger A, Müller CE . P2 receptors activated by uracil nucleotides--an update . Curr. Med. Chem. . 13 . 3 . 289–312 . 2006 . 16475938 . 10.2174/092986706775476052 .
• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 . DNA Res. . 1 . 1 . 27–35 . 1995 . 7584026 . 10.1093/dnares/1.1.27 . free .
• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) . DNA Res. . 1 . 1 . 47–56 . 1995 . 7584028 . 10.1093/dnares/1.1.47 . free .
• Charlton ME, Williams AS, Fogliano M, etal . The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge . Brain Res. . 764 . 1–2 . 141–148 . 1997 . 9295203 . 10.1016/S0006-8993(97)00438-1 . 44648771 . free .
• Joensuu T, Hämäläinen R, Lehesjoki AE, etal . A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q . Genomics . 63 . 3 . 409–416 . 2000 . 10704288 . 10.1006/geno.1999.6096 .
• Chambers JK, Macdonald LE, Sarau HM, etal . A G protein-coupled receptor for UDP-glucose . J. Biol. Chem. . 275 . 15 . 10767–10771 . 2000 . 10753868 . 10.1074/jbc.275.15.10767 . free .
• Wittenberger T, Schaller HC, Hellebrand S . An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors . J. Mol. Biol. . 307 . 3 . 799–813 . 2001 . 11273702 . 10.1006/jmbi.2001.4520 .
• Joensuu T, Hämäläinen R, Yuan B, etal . Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3 . Am. J. Hum. Genet. . 69 . 4 . 673–684 . 2001 . 11524702 . 10.1086/323610 . 1226054 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lazarowski ER, Shea DA, Boucher RC, Harden TK . Release of cellular UDP-glucose as a potential extracellular signaling molecule . Mol. Pharmacol. . 63 . 5 . 1190–1197 . 2003 . 12695547 . 10.1124/mol.63.5.1190 .
• Lee BC, Cheng T, Adams GB, etal . P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells . Genes Dev. . 17 . 13 . 1592–1604 . 2003 . 12842911 . 10.1101/gad.1071503 . 196132 .
• Skelton L, Cooper M, Murphy M, Platt A . Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose . J. Immunol. . 171 . 4 . 1941–1949 . 2003 . 12902497 . 10.4049/jimmunol.171.4.1941. free .
• Moore DJ, Murdock PR, Watson JM, etal . GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function . Brain Res. Mol. Brain Res. . 118 . 1–2 . 10–23 . 2004 . 14559350 . 10.1016/S0169-328X(03)00330-9 .

External links

• Web site: P2Y Receptors: P2Y₁₄ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303174528/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3050 . dead .

Notes and References

1. Web site: Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14.