P2RX2 explained

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.^{[1] [2] [3]}

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a cation conducting ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.

Further reading

• North RA . Molecular physiology of P2X receptors . Physiol. Rev. . 82 . 4 . 1013–67 . 2002 . 12270951 . 10.1152/physrev.00015.2002 .
• Barrera NP, Ormond SJ, Henderson RM, etal . Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize . J. Biol. Chem. . 280 . 11 . 10759–65 . 2005 . 15657042 . 10.1074/jbc.M412265200 . free .
• Mason HS, Bourke S, Kemp PJ . Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species . Mol. Pharmacol. . 66 . 6 . 1525–35 . 2005 . 15331767 . 10.1124/mol.104.000851 . 24536809 .
• Aschrafi A, Sadtler S, Niculescu C, etal . Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes . J. Mol. Biol. . 342 . 1 . 333–43 . 2004 . 15313628 . 10.1016/j.jmb.2004.06.092 .
• Boué-Grabot E, Emerit MB, Toulmé E, etal . Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels . J. Biol. Chem. . 279 . 8 . 6967–75 . 2004 . 14660627 . 10.1074/jbc.M307772200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Järlebark LE, Housley GD, Raybould NP, etal . ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea . NeuroReport . 13 . 15 . 1979–84 . 2003 . 12395104 . 10.1097/00001756-200210280-00030 . 10991307 .
• Khakh BS, Zhou X, Sydes J, etal . State-dependent cross-inhibition between transmitter-gated cation channels . Nature . 406 . 6794 . 405–10 . 2000 . 10935636 . 10.1038/35019066 . 2000Natur.406..405K . 4500837 .
• Brändle U, Spielmanns P, Osteroth R, etal . Desensitization of the P2X(2) receptor controlled by alternative splicing . FEBS Lett. . 404 . 2–3 . 294–8 . 1997 . 9119082 . 10.1016/S0014-5793(97)00128-2 . 39951168 . free . 1997FEBSL.404..294B .
• Lewis C, Neidhart S, Holy C, etal . Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons . Nature . 377 . 6548 . 432–5 . 1995 . 7566120 . 10.1038/377432a0 . 1995Natur.377..432L . 4361850 .

Notes and References

1. Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF . Molecular and functional characterization of human P2X(2) receptors . Mol Pharmacol . 56 . 6 . 1171–81 . Dec 1999 . 10570044 . 10.1124/mol.56.6.1171.
2. Brake AJ, Wagenbach MJ, Julius D . New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor . Nature . 371 . 6497 . 519–23 . Oct 1994 . 7523952 . 10.1038/371519a0 . 1994Natur.371..519B . 4371044 .
3. Web site: Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2.