Otter Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of St. Francis River within Lake Wappapello.
The stream headwaters arise at 37.1344°N -90.6289°W and the confluence with the St. Francis is at 36.9842°N -90.3803°W at an elevation of .
Otter Creek most likely was so named on account of otters near its course.[1]