OpenPHACTS explained

Open PHACTS (Open Pharmacological Concept Triple Store) was a European initiative public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery.^{[1] [2] [3] [4]} It has been funded by the Innovative Medicines Initiative,^[5] selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".^{[6] [7]}

Partnerships

A total of 27 partners were involved including:

• Academia: Maastricht University, University of Santiago de Compostela, University of Vienna, University of Manchester, University of Bonn, Swiss Institute of Bioinformatics, European Bioinformatics Institute, Vrije Universiteit of Amsterdam, Technical University of Denmark, University of Hamburg
• Pharmaceutical companies: Pfizer, Merck KGaA, Eli Lilly and Company, Novartis, GlaxoSmithKline, AstraZeneca
• Other companies: ChemSpider, Biovia, Eagle Genomics, Entagen
• Publishers: Royal Society of Chemistry, Thomson Reuters

Drug discovery

The Open Pharmacological Space created by the consortium intended to support open innovation and in-house non-public drug discovery research^[8] by removing bottlenecks in drug development.^{[9] [10]} Resources from the project are publicly available on GitHub.^[11]

To reduce the barriers to drug discovery in industry, academia and for small businesses, the Open PHACTS consortium built the Open PHACTS Discovery Platform. This platform was freely available, integrating pharmacological data from a variety of information resources and providing tools and services to question this integrated data to support pharmacological research.

Notes and References

1. Williams . A. J. . Antony John Williams. Harland . L. . Groth . P. . Pettifer . S. . Steve Pettifer. Chichester . C. . Willighagen . E. L. . Evelo . C. T. . Blomberg . N. . Ecker . G. . Gerhard Ecker. Goble . C. . Carole Goble. Mons . B. . Barend Mons. Open PHACTS: Semantic interoperability for drug discovery . 10.1016/j.drudis.2012.05.016 . Drug Discovery Today. 17 . 21–22 . 1188–1198 . 2012 . 22683805 . free .
2. Ecker . G. F. . Williams-Jones . B. . 10.1002/minf.201280004 . Open Innovation in Drug Discovery . Molecular Informatics. 31 . 8 . 519–520 . 2012 . 27477598 . free .
3. Alasdair J.G. . Gray. Paul . Groth. Antonis . Loizou. Sune . Askjaer. Christian . Brenninkmeijer. Kees . Burger. Christine. Chichester. Chris T. . Evelo. Carole . Goble. Carole Goble. Lee . Harland. Steve. Pettifer. Steve Pettifer. Mark. Thompson. Andra. Waagmeester. Antony John. Williams. Antony John Williams. 10.3233/SW-2012-0088. Applying linked data approaches to pharmacology: Architectural decisions and implementation. Semantic Web. 5 . 2. 101–113. 2014 . 1005.2643.
4. 24267948. 2013. Ciccarese. P. PAV ontology: Provenance, authoring and versioning. Journal of Biomedical Semantics. 4. 1. 37. Soiland-Reyes. S. Belhajjame. K. Gray. A. J.. Goble. C. Clark. T. 10.1186/2041-1480-4-37. 1304.7224. 4177195. free.
5. Web site: Open PHACTS at IMI - The Innovative Medicines Initiative .
6. Watson . R. . 10.1136/bmj.d1577 . Europe provides €172m for research into innovative medicines . BMJ . 342 . d1577 . 2011 . 21393337. 40608990 .
7. Book: 10.1007/978-3-642-41338-4_5. Incorporating Commercial and Private Data into an Open Linked Data Platform for Drug Discovery. Advanced Information Systems Engineering. 8219. 65–80. Lecture Notes in Computer Science. 2013. Goble . C. . Carole Goble. Gray . A. J. G. . Harland . L. . Karapetyan . K. . Loizou . A. . Mikhailov . I. . Rankka . Y. N. . Senger . S. . Tkachenko . V. . Williams . A. J. . Antony John Williams. Willighagen . E. L. . 978-3-642-41337-7.
8. Müller . S. . Weigelt . J. . Open-access public-private partnerships to enable drug discovery--new approaches . IDrugs: The Investigational Drugs Journal . 13 . 3 . 175–180 . 2010 . 20191434.
9. Dalgleish . R. . Molero . E. . Kidd . R. . Jansen . M. . Past . D. . Robl . A. . Mons . B. . Diaz . C. . Mons . A. . Brookes . A. J. . Solving bottlenecks in data sharing in the life sciences . 10.1002/humu.22123 . Human Mutation . 33 . 10 . 1494–1496 . 2012 . 22623360 . free .
10. Mons . B. . Barend Mons. Van Haagen . H. . Chichester . C. . Hoen . P. B. 'T. . Den Dunnen . J. T. . Van Ommen . G. . Van Mulligen . E. . Singh . B. . Hooft . R. . Roos . 10.1038/ng0411-281 . M. . Hammond . J. . Kiesel . B. . Giardine . B. . Velterop . J. . Jan Velterop. Groth . P. . Schultes . E. . The value of data . Nature Genetics . 43 . 4 . 281–283 . 2011 . 21445068. free .
11. Web site: Open PHACTS on GitHub . . 2012-07-10.