OSBPL1A explained
Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.[1] [2] [3]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.[4]
Further reading
- Lehto M, Laitinen S, Chinetti G, etal . The OSBP-related protein family in humans. . J. Lipid Res. . 42 . 8 . 1203–13 . 2001 . 10.1016/S0022-2275(20)31570-4 . 11483621 . free .
- Jaworski CJ, Moreira E, Li A, etal . A family of 12 human genes containing oxysterol-binding domains. . Genomics . 78 . 3 . 185–96 . 2002 . 11735225 . 10.1006/geno.2001.6663 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Johansson M, Bocher V, Lehto M, etal . The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct. . Mol. Biol. Cell . 14 . 3 . 903–15 . 2004 . 12631712 . 10.1091/mbc.E02-08-0459 . 151568 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Johansson M, Lehto M, Tanhuanpää K, etal . The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. . Mol. Biol. Cell . 16 . 12 . 5480–92 . 2006 . 16176980 . 10.1091/mbc.E05-03-0189 . 1289395 .
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Xu Y, Liu Y, Ridgway ND, McMaster CR . Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport . J Biol Chem . 276 . 21 . 18407–14 . May 2001 . 11279184 . 10.1074/jbc.M101204200 . free .
- Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E . Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism . J Lipid Res . 40 . 12 . 2204–11 . Feb 2000 . 10.1016/S0022-2275(20)32095-2 . 10588946 . free .
- Web site: Entrez Gene: OSBPL1A oxysterol binding protein-like 1A.
- Web site: Entrez Gene: OSBPL1A oxysterol binding protein-like 1A.
