OAS3 explained

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.^{[1] [2]}

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligomers activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.^[3]

Further reading

• Hovanessian AG, Justesen J . The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation. . Biochimie . 89 . 6–7 . 779–88 . 2007 . 17408844 . 10.1016/j.biochi.2007.02.003 .
• Silverman RH, Sengupta DN . Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. . J. Exp. Pathol. . 5 . 2 . 69–77 . 1991 . 1708818 .
• Hovanessian AG, Laurent AG, Chebath J, etal . Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. . EMBO J. . 6 . 5 . 1273–80 . 1987 . 2440675 . 10.1002/j.1460-2075.1987.tb02364.x. 553929 .
• Marié I, Blanco J, Rebouillat D, Hovanessian AG . 69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters. . Eur. J. Biochem. . 248 . 2 . 558–66 . 1997 . 9346316 . 10.1111/j.1432-1033.1997.t01-1-00558.x . free .
• Rebouillat D, Hovnanian A, Marié I, Hovanessian AG . The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains. . J. Biol. Chem. . 274 . 3 . 1557–65 . 1999 . 9880533 . 10.1074/jbc.274.3.1557 . free .
• Rebouillat D, Hovnanian A, David G, etal . Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase. . Genomics . 70 . 2 . 232–40 . 2001 . 11112351 . 10.1006/geno.2000.6382 .
• Ito M, Shichijo S, Tsuda N, etal . Molecular basis of T cell-mediated recognition of pancreatic cancer cells. . Cancer Res. . 61 . 5 . 2038–46 . 2001 . 11280764 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SE, Muzny DM, Buhay CJ, etal . The finished DNA sequence of human chromosome 12. . Nature . 440 . 7082 . 346–51 . 2006 . 16541075 . 10.1038/nature04569 . 2006Natur.440..346S . free .

Notes and References

1. Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG . The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms . Genomics . 52 . 3 . 267–77 . Dec 1998 . 9790745 . 10.1006/geno.1998.5443 .
2. Web site: Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa.
3. Web site: Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa.