O-phospho-L-serine—tRNA ligase explained

O-phospho-L-serine—tRNA ligase (O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction:

ATP + O-phospho-L-serine + tRNACys

AMP + diphosphate + O-phospho-L-seryl-tRNACys

In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.

Notes and References

1. Fukunaga R, Yokoyama S . Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea . Nature Structural & Molecular Biology . 14 . 4 . 272–9 . April 2007 . 17351629 . 10.1038/nsmb1219 . 10959763 .
2. Hauenstein SI, Perona JJ . Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei . The Journal of Biological Chemistry . 283 . 32 . 22007–17 . August 2008 . 18559341 . 2494925 . 10.1074/jbc.M801839200 . free .