Nucleoporin 205 Explained
Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.[1] [2] [3]
Function
Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.[1] It has also been recently shown that Nup205 is required for proper viral gene expression.[4]
Further reading
- Hawryluk-Gara LA, Shibuya EK, Wozniak RW . Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex . Mol. Biol. Cell . 16 . 5 . 2382–94 . 2005 . 15703211 . 1087243 . 10.1091/mbc.E04-10-0857 .
- Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E . Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly . Mol. Biol. Cell . 8 . 10 . 2017–38 . 1997 . 9348540 . 25664 . 10.1091/mbc.8.10.2017 .
- Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S . Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1 . J. Biol. Chem. . 277 . 47 . 45091–8 . 2002 . 12228227 . 10.1074/jbc.M207439200 . free .
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
- Hase ME, Cordes VC . Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex . Mol. Biol. Cell . 14 . 5 . 1923–40 . 2003 . 12802065 . 165087 . 10.1091/mbc.E02-09-0620 . 11858/00-001M-0000-0028-3D33-F .
- Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Res. . 3 . 5 . 321–9, 341–54 . 1996 . 9039502 . 10.1093/dnares/3.5.321 . free .
- Sowa ME, Bennett EJ, Gygi SP, Harper JW . Defining the human deubiquitinating enzyme interaction landscape . Cell . 138 . 2 . 389–403 . 2009 . 19615732 . 2716422 . 10.1016/j.cell.2009.04.042 .
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
Notes and References
- Web site: Entrez Gene: NUP205 nucleoporin 205kDa.
- Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Res. . 3 . 5 . 321–9, 341–54 . October 1996 . 9039502 . 10.1093/dnares/3.5.321 . free .
- Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E . Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly . Mol. Biol. Cell . 8 . 10 . 2017–38 . October 1997 . 9348540 . 25664 . 10.1091/mbc.8.10.2017 .
- Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG . Nov 2014 . Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression . J Virol . 88 . 22. 13249–59 . 10.1128/JVI.00933-14 . 25210169 . 4249058 .
