| Official Name: | North Santee, South Carolina |
| Settlement Type: | Census-designated place |
| Pushpin Map: | South Carolina#USA |
| Pushpin Label: | North Santee |
| Pushpin Label Position: | left |
| Coordinates: | 33.5303°N -80.4264°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Clarendon |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 11.16 |
| Area Land Sq Mi: | 9.11 |
| Area Water Sq Mi: | 2.05 |
| Area Total Km2: | 28.90 |
| Area Land Km2: | 23.59 |
| Area Water Km2: | 5.31 |
| Population As Of: | 2020 |
| Population Density Km2: | 31.76 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 80 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 29148 (Summerton) |
| Area Code: | 803/839 |
| Blank Name: | FIPS code |
| Blank Info: | 45-51367 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2804703 |
| Population Total: | 749 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 82.24 |
North Santee is a census-designated place (CDP) in Clarendon County, South Carolina, United States. It was first listed as a CDP prior to the 2020 census with a population of 749.[2]
The CDP is on the southwestern edge of Clarendon County, on the northeast shore of Lake Marion, a reservoir on the Santee River. Interstate 95 crosses Lake Marion at North Santee, with access from Exit 102. U.S. Routes 15 and 301 pass through the CDP as a surface highway, joining I-95 at Exit 102 to cross the lake. Summerton is 7miles to the northeast, and Santee is 5miles to the southwest in Orangeburg County.
Santee Indian Mound and Fort Watson is a historic site in the north part of the CDP, near the shore of Lake Marion.
| White alone (NH) | 639 | 85.31% | |
| Black or African American alone (NH) | 79 | 10.55% | |
| Native American or Alaska Native alone (NH) | 0 | 0.00% | |
| Asian alone (NH) | 3 | 0.40% | |
| Pacific Islander alone (NH) | 0 | 0.00% | |
| Some Other Race alone (NH) | 0 | 0.00% | |
| Mixed Race/Multi-Racial (NH) | 20 | 2.67% | |
| Hispanic or Latino (any race) | 8 | 1.07% | |
| Total | 749 | 100.00% |
It is in Clarendon School District 1.[4]