| North Fork Popo Agie River | |
| Name Etymology: | word po-PO-shuh, meaning "Head River" or possibly "Gurgling River" |
| Map: | North_Fork_Popo_River_Flow.png |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Wyoming |
| Length: | 43miles |
| Source1: | Lonesome Lake |
| Source1 Location: | Wind River Range, Fremont County |
| Source1 Elevation: | 10200feet |
| Mouth Location: | near Lander, Wyoming |
| Mouth Coordinates: | 42.8542°N -108.6998°W |
| Mouth Elevation: | 5000feet |
| Tributaries Left: | Surrell Creek |
| Tributaries Right: | Shoshone Lake, Paradise Creek, Mexican Creek |
The North Fork Popo Agie River serves as part of the boundary between the Wind River Indian Reservation and Fremont County Wyoming. The river's headwaters are at Lonesome Lake in the Wind River Range, and it flows eastward until its end near Lander, Wyoming when it joins the Middle Fork Popo Agie River.
The river is considered a Class 2 fishery by the Wyoming Game and Fish Department meaning it has very good trout waters of statewide importance. Different species of fish can be found, including rainbow trout, brook trout, cutthroat trout and mountain whitefish